Construction of physiological, hematological and biochemical databases for the "Lifespan Prediction Model"

本研究的目的是1）基于生理学、血液学和生化学的横截面数据来检查寿命与体力（活力年龄）之间的关系; 2）通过<Lifespan Prediction Model>比较体力较低的中老年人和体力较高的人来评估使用寿命估计的有效性。身体活力基于贫血、血清胆固醇水平、敏捷性和有氧工作能力的健康/健身信息的组合。本研究的参与者是232名日本人（78名男性和157名女性，年龄27-91岁），他们接受了身体活力评估。在1991年至2005年的随访研究期间，有12人（9名男性和3名女性）死亡。本研究试图验证从实际年龄和生命年龄（以体力指数为基础）之间的差异可以预测寿命的假设，得到以下结果：1.在随访期间死亡的心血管疾病和糖尿病患者的体力指数相对较低，表现为贫血、低HDL C和基线时较低的体能水平。2.经常锻炼的冠状动脉患者的生命年龄明显低于停止锻炼的患者。这些结果表明，长时间（5年或更长时间）的锻炼习惯对冠状动脉患者的身体活力有有利影响，支持使用身体活力的寿命预测模型包括贫血、血清胆固醇水平、敏捷性和摄氧量。

The purposes of this study were 1)to examine the relationship between lifespan and physical vitality (vital age) based on physiological, hematological and biochemical cross-sectional data, and 2)to evaluate the validity of estimating lifespan using the <Lifespan Prediction Model> by comparing middle-aged and older adults with lower physical vitality to those with higher physical vitality. Physical vitality was based on a combination of health/fitness information for anemia, serum cholesterol level, agility and aerobic work capacity. Participants in this study were 232 Japanese people (78 men and 157 women, aged 27-91 years) who underwent the physical vitality assessment. During the follow-up study period from 1991 to 2005,twelve people (9 men and 3 women) died. This study attempted to test the hypothesis that lifespan can be predicted from the difference between chronological age and vital age (based on physical vitality scores).The following results were obtained : 1.Patients with cardiovascular disease and diabetes mellitus who died during the follow-up period had relatively lower physical vitality as evidenced by anemia, lower HDLC, and lower physical fitness level at baseline. 2.Vital age for regularlyexercising coronary patients was significantly younger than patients who stopped exercising.These results indicate that exercise habituation for an extended period of time (5 years or more) favorably affects the physical vitality of coronary patients, supporting a model of lifespan prediction using physical vitality consisting of anemia, serum cholesterol level, agility and oxygen uptake.