Development of osteoconductive materials using ion conductive ceramics

使用离子导电陶瓷开发骨传导材料

• 批准号: 15360338
• 负责人: NAKAMURA Satoshi
• 金额: $ 9.73万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15360338/
• 关键词: Hydroxyapatite; Ionic conductivity; Polarization; Oteoconductivity; Surface charges; Bioactive glass; Zirconia; Early stage cell adhesion; 電気分極; 骨組織伝導; セラミックス; 初期接着; 吸着; 細胞外基質

Large surface charges were demonstrated to be inducible on ionic conductive ceramics by ion transport polarization based on thermally stimulated depolarization measurements. We have been demonstrated by simulated body fluid tests that the negative, surface charges induced by the electrical polarization increased the overgrowth conductivity on the ionic conductive ceramic surface but that the positive charge diminished the overgrowth ability. The charge-induced surfaces of the ionic conductive ceramics promoted bone reconstructions in wide defects of canine bones at 7days after the implantation, whereas the processes varied according to the charge polarity. The idea of the activated field concerning the in vitro overgrowth should be extensible into the in vivo calcification reactions of the electrically polarized ionic conductive ceramics implanted in bone tissues. Moreover, we have proved that the electrical polarization techniques were applicable not only to hydroxyapatite but also to zirconia and bioactive glass and established the electrical polarization technologies for ionic conductive ceramics.

基于热刺激去极化的离子传输极化实验表明，离子导电陶瓷表面可以产生大的表面电荷。通过模拟体液实验，我们证明了电极化引起的表面负电荷增加了离子导电陶瓷表面的生长电导率，而正电荷降低了生长能力。离子导电陶瓷的电荷诱导表面在植入后7d促进了犬骨大范围缺损区的骨重建，但这一过程随电荷极性的不同而不同。关于体外过度生长的激活场的概念应该推广到植入骨组织的电极化离子导电陶瓷的体内钙化反应中。此外，我们还证明了电极化技术不仅适用于羟基磷灰石，也适用于氧化锆和生物活性玻璃，建立了离子导电陶瓷的电极化技术。

项目成果

Synthesis of Bioactive Zirconia Ceramics on the Basis of Vector Materials Science

基于载体材料科学的生物活性氧化锆陶瓷的合成

• 发表时间: 2005
• 期刊: J.Jpn.Soc.Powder Powder Metallurgy 52(5)
• 作者: Yamashita K;Nakamura S;Kishi S;Inuzuka M;Nishio K;Hashimoto K;Toda Y
• 通讯作者: Toda Y

Osseous Cell Response to Electrostatic Stimulations of Poled Hydroxyapatite Ceramics in Canine Diaphyses

犬骨干中极化羟基磷灰石陶瓷静电刺激的骨细胞反应

• 发表时间: 2004
• 期刊: Key Engineering Materials 254-256
• 作者: Nakamura S;Nakamura M;Kobayashi T;Sekijima Y;Kasugai S;Yamashita K.
• 通讯作者: Yamashita K.

Effect of Electrical Polarization of B-type Carbonated Hydroxyapatite

B型碳酸羟基磷灰石的电极化效应

• 发表时间: 2004
• 期刊: Phosphorus Research Bulletin 17
• 作者: Tanaka K;Nakamura S;Yoshida K;Hashimoto K;Toda Y;Yamashita K.
• 通讯作者: Yamashita K.

Molecular biologic detections of cell activation related proteins on polarized hydroxyapatite

极化羟基磷灰石上细胞活化相关蛋白的分子生物学检测

• 发表时间: 2003
• 期刊: Key Engineering Materials, Bioceramics 15 240-242
• 作者: Nakamura M;Sekijima Y;Kobayashi T;Nakamura S;Yamashita K.
• 通讯作者: Yamashita K.

Synthesis of new biocompatible apatite-type rare-earth silicate

新型生物相容性磷灰石型稀土硅酸盐的合成

• 发表时间: 2003
• 期刊: Key Engineering Materials, Bioceramics 15 240-242
• 作者: Kizuki T;Ohgaki M;Nakamura S;Hashimoto K;Toda Y;Yamashita K.
• 通讯作者: Yamashita K.