Development of osteoconductive materials using ion conductive ceramics

基于热激去极化测量的离子传导陶瓷的离子输运极化表明，大的表面电荷是可诱导的。我们已经通过模拟体液测试证明，由电极化引起的负表面电荷增加了离子导电陶瓷表面上的过度生长导电性，但是正电荷减少了过度生长能力。离子导电陶瓷的电荷诱导表面在植入后7天促进了犬骨宽缺损的骨重建，但该过程因电荷极性而异。关于体外过度生长的激活场的概念应该扩展到植入骨组织的电极化离子导电陶瓷的体内钙化反应。此外，我们还证明了电极化技术不仅适用于羟基磷灰石，而且适用于氧化锆和生物活性玻璃，并建立了离子导电陶瓷的电极化技术。

Large surface charges were demonstrated to be inducible on ionic conductive ceramics by ion transport polarization based on thermally stimulated depolarization measurements. We have been demonstrated by simulated body fluid tests that the negative, surface charges induced by the electrical polarization increased the overgrowth conductivity on the ionic conductive ceramic surface but that the positive charge diminished the overgrowth ability. The charge-induced surfaces of the ionic conductive ceramics promoted bone reconstructions in wide defects of canine bones at 7days after the implantation, whereas the processes varied according to the charge polarity. The idea of the activated field concerning the in vitro overgrowth should be extensible into the in vivo calcification reactions of the electrically polarized ionic conductive ceramics implanted in bone tissues. Moreover, we have proved that the electrical polarization techniques were applicable not only to hydroxyapatite but also to zirconia and bioactive glass and established the electrical polarization technologies for ionic conductive ceramics.