The Study of Genetic Adaptation to Malaria in Nepal-In Comparison with Cultural Adaptation

尼泊尔疟疾遗传适应研究——与文化适应的比较

• 批准号: 15406009
• 负责人: KOBAYASHI Shigeru
• 金额: $ 6.4万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15406009/
• 关键词: malaria; abnormal hemoglobin; α^+thalassemia; G6PD deficiency; Nepal; Malaria Hypothesis; Plasmodium vivax; Plasmodium falciparum; αサラセミア; 熱帯熱

The main purpose of this project is to elucidate the relation between the hereditary RBC disorders such as α-thalassemia and malaria infection among children in a lowland area of Nepal. Up to the present research, we confirmed that the prevalence of malaria is significantly low among the subjects who have α^+-thalassemia genes than those who have not them in the area concerned. However, the prevalence of malaria among the children younger than ten years old was generally low even among those who have not this kind of gene.In order to collect the samples, we carried out field research four times in close cooperation with the teachers of the Shree Dedee Thumka Lower Scondary School in Mahadevsthan Village Development Committee, Kavre-Palanchok District. During our field research, the Maoist, the armed political group in Nepal, has been active, and we had to postpone the schedule of the first research to be conducted in September 2003. However, we had no trouble since the research in Dece … More mber 2003 up to that in September 2005. Every time, we collected samples from approximately 200 children.We are analyzing the samples not only for the detection of RBC disorders including α^+-thalassemia genes, but also for that of malaria infection. The prevalence of α^+-thalassemia by ethnic groups is similar to that of adults. The rate of malaria infection was low even in the post-monsoon season, when the transmission of the parasites wass active. Now we are preparing the detection IgG and IgM antibodies to malaria among children in order to examine their infection in the recent past.We published a paper concerning the prevalence of filariasis in the same area (Watanabe et al. 2003) We also prepared the paper on the correlation between the peoples' attitudes about malaria and the prevalence of hereditary RBC disorders on the basis of the research from 2000 to 2002. The paper on the difference of malaria infection in relation to the frequency of α^+-thalassemia is under preparation. In addition we published a paper concerning diabetes comparing the data obtained in 1990 in the same area with those reported recently by Nepalese researchers. Less

该项目的主要目的是阐明尼泊尔低地地区儿童中遗传性红细胞疾病如α-地中海贫血与疟疾感染之间的关系。到目前为止，我们证实，在相关地区，携带α^+地中海贫血基因的受试者中疟疾的患病率显著低于不携带该基因的受试者。为了收集样本，我们与Kavre-Palanchok区Mahadevsthan村发展委员会Shree Dedee Thumka Lower Sconnut学校的教师密切合作，进行了四次实地调查。在我们的实地研究期间，尼泊尔的武装政治集团毛派一直很活跃，我们不得不推迟原定于2003年9月进行的第一次研究。然而，自从在Dece进行研究以来，我们没有遇到任何麻烦 ...更多信息 从2003年9月到2005年9月。我们每次都从大约200名儿童身上采集样本，分析这些样本不仅是为了检测包括α^+地中海贫血基因在内的红细胞疾病，还为了检测疟疾感染。不同种族人群的α^+地中海贫血患病率与成人相似。即使在寄生虫传播活跃的季风季节后，疟疾感染率也很低。目前正在做儿童疟疾IgG、IgM抗体检测，以了解儿童近期感染情况，并发表了有关该地区丝虫病流行情况的论文（Watanabe等人，2003年）我们还根据2000年至2010年的研究，编写了关于人们对疟疾的态度与遗传性红细胞疾病患病率之间的相关性的论文。2002.关于疟疾感染率与α^+地中海贫血发生率之间的差异的论文正在编写之中。此外，我们发表了一篇关于糖尿病的论文，将1990年在同一地区获得的数据与尼泊尔研究人员最近报告的数据进行了比较。少

项目成果

Bancroftian filariasis in Nepal : a survey for circulating antigenomia of Wuchereria bancrofti and urinart IgG4 antibody in two rural areas of Nepal.

尼泊尔班克罗夫特丝虫病：对尼泊尔两个农村地区乌切氏菌班克罗夫特丝虫和 urinart IgG4 抗体循环反基因组的调查。

• 发表时间: 2003
• 期刊: Acta Tropica, 88(1)
• 作者: Watanabe;K.;Itoh;M.;Matsuyama;H.;Hamano;S.et al.
• 通讯作者: S.et al.

マラリアに関連する赤血球遺伝子の頻度と住民のマラリア観の関係

疟疾相关红细胞基因频率与居民疟疾看法的关系

• 发表时间: 2005
• 期刊: 日本地理学会発表要旨集 67
• 作者: 小林 茂;濱野真二郎ほか
• 通讯作者: 濱野真二郎ほか

ネパールにおけるマラリアに対する文化的・生物学的適応:ヘモグロビン異常とマラリア

尼泊尔对疟疾的文化和生物适应：血红蛋白异常和疟疾

• 发表时间: 2005
• 期刊: 医学のあゆみ 212(4)
• 作者: 濱野真二郎;小林 茂
• 通讯作者: 小林 茂

Bancroftian filariasis in Nepal : a survey for circulating antigenomia of Wuchereria bancrofti and urinary IgG4 antibody in two rural areas of Nepal.

尼泊尔班克罗夫特丝虫病：尼泊尔两个农村地区班克罗夫特丝虫循环反基因组和尿 IgG4 抗体的调查。

• 发表时间: 2003
• 期刊: Acta Tropica 88(1)
• 作者: Watanabe;K.;Itoh;M.;Matsuyama;H.;Hamano;S.;Kobayashi;S.;Shirakawa;T.;Suzuki;A.;Sharma;S.;Acharya;G.P.;Itoh;K.;Kawasaki;T.;Kimura;E.;Aoki;Y.
• 通讯作者: Y.

The prevalence of diabetes mellitus and impaired fasting glucose/gleicaemia (IFG) in suburban Kathmandu

加德满都郊区糖尿病和空腹血糖/糖血症（IFG）受损的患病率

• 发表时间: 2005
• 期刊: Journal of Health Science 27
• 作者: Sasaki;H.;Kawasaki;T.;Ogaki;T.;Kobayashi;S.et al.
• 通讯作者: S.et al.