Surface modification of shape memory alloys with bio-functional polymers for medical application

医用生物功能聚合物形状记忆合金的表面改性

• 批准号: 16300152
• 负责人: YONEYAMA Takayuki
• 金额: $ 9.73万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16300152/
• 关键词: Ti-Ni alloy; MPC polymer; Coating; Super-elasticity; Surface modification; Stent

1.Super-elasticity of Ti-Ni alloy(1)Composition of Ti-Ni alloy suitable for super-elasticity at body temperature was investigated by tensile test and DSC. It was found that the composition around Ti-50.85Ni (mol%) was suitable for the purpose.(2)It was found that the heat treatment condition effective to improve the mechanical property of Ti-Ni alloy was between 713 and 773 K for about 0.9 ks.(3)Fatigue strength of the alloy castings was evaluated to be similar to those of CP titanium or Ti-6A1-4V alloy castings.2.Design and fabrication of the alloy stentsStent models were fabricated with Ti-Ni alloy tubes by laser micro-cutting method based on the basic design of self-expanding type stent with super-elasticity.3.Coating on Ti-Ni alloy with bio-fuctional polymers(1)Poly (MPC-co-BMA) with a 0.30 MPC mole fraction (PMB 30) was synthesized as a blood compatible MPC polymer alloy for coating.(2)PMB 30 was coated on the surface of Ti-Ni alloy specimens by spin coating. As the result, the PMB 30 coating layer was not uniform at the marginal part, however, the thickness of the layer decreased with increasing immersion period and became stable at 15-20 nm after 72 h immersion in saline solution.4.Surface modification of Ti-Ni alloy(1)Thickness of the surface oxide layer of Ti-Ni alloy increased, and titanium in the layer was oxidized to Ti^<4+> and became more stable by electrolytic treatment.(2)Nickel concentration in the surface oxide layer decreased after electrolytic treatment, especially by the GLW treatment with the electrolyte composed of glycerol, lactic acid, and water. This treatment was effective in improving the corrosion resistance of Ti-Ni alloy.It was concluded that it was possible to develop new and safe medical devices including stents with superior property in mechanical function, blood compatibility, and corrosion resistance.

1.钛镍合金的超弹性(1)通过拉伸试验和差示扫描量热仪(DSC)研究了适合于体温超弹性的钛镍合金成分。(2)发现提高钛镍合金力学性能的有效热处理条件是在713~773K之间进行0.9k左右的热处理。(3)合金铸件的疲劳强度与CP钛或Ti-6Al-4V合金铸件的疲劳强度相近。2.合金支架的设计与制造(1)合成了摩尔分数为0.30MPC的聚(MPC-co-BMA)涂层。(2)采用旋涂的方法在钛镍合金表面涂覆了PMB-30。4.钛镍合金的表面改性：(1)钛镍合金表面氧化层厚度增加，层中钛被氧化为Ti4+，经电解处理后更稳定。(2)电解处理后，表面氧化层中的镍含量降低，尤其是以甘油、乳酸和水为电解液的GLW处理后，表面氧化层中的镍含量降低。该处理有效地提高了钛镍合金的耐腐蚀性，为开发具有优异机械性能、血液相容性和耐腐蚀性的支架等新型安全医疗器械提供了可能。

项目成果

チタンニッケル合金、チタンニッケル合金の表面改質方法および生体親和材

钛镍合金、钛镍合金的表面改性方法及生物相容性材料

• 发表时间: 2006

Bending property of super-elastic Ti-Ni alloy dental castings with different heat treatments

不同热处理超弹性钛镍合金牙科铸件的弯曲性能

• 发表时间: 2007
• 期刊: Mater Trans 18(3)
• 作者: Yoneyana T;Doi H;et al.
• 通讯作者: et al.