The Association of Fetal Malnutrition with Metabolic Syndrome in Adulthood

胎儿营养不良与成年代谢综合征的关系

• 批准号: 16390475
• 负责人: ITOH Hiroaki
• 金额: $ 9.15万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390475/
• 关键词: pregnancy; fetus; metabolic syndrome; nutrition; medical welfare; IUGR; 栄養; fetal programming; 肥満; 高血圧; 糖尿病

The purpose of the present study was to investigate a possible mechanism of developmental origins of metabolic syndrome.We developed a mouse animal model of fetal undernutrition (UN offspring) by maternal food restriction. The UN offspring developed an acceleration of obesity on high fat diet, dyslipidemia, impaired glucose tolerance and blood pressure increase in adulthood. In the UN offspring, we reveled a premature onset of leptin surge during neonatal period, which programmed permanent low leptin sensitivity in the hypothalamic energy regulation, concomitant with structural changes of hypothalamic neuronal circuit, such as neuropeptide Y (NPY) and cocaine and amphetamine regulated transcript (CART), contributing to an acceleration of obesity on high fat diet as well as impaired glucose metabolism (Yura S, Itoh H et al., Cell Metab, 2005,1,371).Thus, we here demonstrated that premature leptin surge during neonatal period plays a pivotal role in the developmental origins of obesity and associated detrimental metabolic disorders.

为探讨代谢综合征发生的可能机制，本研究通过母体限食建立了一种胎儿营养不良（UN仔）小鼠动物模型。UN后代在成年期出现了高脂饮食加速肥胖、血脂异常、糖耐量受损和血压升高。在UN后代中，我们揭示了在新生儿时期瘦素激增的过早发作，其在下丘脑能量调节中编程永久性低瘦素敏感性，伴随着下丘脑神经元回路的结构变化，如神经肽Y（NPY）和可卡因和安非他明调节的转录物（CART），导致高脂肪饮食的肥胖加速以及葡萄糖代谢受损（Yura S，Itoh H等人，Cell Metab，2005，1，371）。因此，我们在这里证明了新生儿时期过早的瘦素激增在肥胖和相关有害代谢障碍的发育起源中发挥着关键作用。

项目成果

Significant increase in maternal plasma leptin concentration in induced delivery: A possible contribution of pro-inflammatory cytokines to placental leptin secretion

• DOI: 10.1507/endocrj.51.177
• 发表时间: 2004-04-01
• 期刊: ENDOCRINE JOURNAL
• 影响因子: 2
• 作者: Nuamah, MA;Yura, S;Fujii, S
• 通讯作者: Fujii, S

Cyclic mechanical stretch augments hyaluronan production in cultured human uterine cervical fibroblast cells

• DOI: 10.1093/molehr/gah229
• 发表时间: 2005-09-01
• 期刊: MOLECULAR HUMAN REPRODUCTION
• 影响因子: 4
• 作者: Takemura, M;Itoh, H;Fujii, S
• 通讯作者: Fujii, S

Cyclic mechanical stretch and interleukin -1αsynergisticaly up -regulate prostacyclin secretion in cultured human uterine myometrial cells

循环机械拉伸和白细胞介素-1α协同上调培养的人子宫肌层细胞中前列环素的分泌

• 发表时间: 2004
• 期刊: Gynecol Endocrinol 18
• 作者: Kakui K;Itoh H 他;Kakui K;Korita D
• 通讯作者: Korita D

Cyclic mechanical stretch and interleukin-1αsynergisticaly up-regulate prostacyclin secretion in cultured human uterine myometrial cells

循环机械拉伸和白介素-1α协同上调培养的人子宫肌层细胞中前列环素的分泌

• 发表时间: 2004
• 期刊: Gynecol Endocrinol 18
• 作者: Kakui K;Itoh H 他;Kakui K;Korita D;Nuamah MA;Korita D;Takemura M;Korita D
• 通讯作者: Korita D

Experimental Transplantation Study for Possible Transformation of Bone Marrow Cells in the Mouse Placenta

小鼠胎盘骨髓细胞可能转化的实验移植研究

• 发表时间: 2005
• 期刊: Placenta 26・8-9
• 作者: 鈴木彩子;他;鈴木彩子;Kazuyo Kakui
• 通讯作者: Kazuyo Kakui