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Preventive effects of masticatory stimulus on senile dementia : a fMRI study

咀嚼刺激对老年痴呆症的预防作用：功能磁共振成像研究

基本信息

批准号：
16390568
负责人：
ONOZUKA Minoru
金额：
$ 9.28万
依托单位：
Kanagawa Dental College
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

项目摘要

The goal of this project is to elucidate the crosstalk mechanism(s) between the masticatory organs and the cerebral cortex including the hippocampus. Especially, we focused on the preventive effects of occlusal or masticatory stimulus on memory processes in aged humans, by the functional magnetic resonance imaging (fMRI) and behavioral science. In the first experiment, using fMRI during cycles of rhythmic gum-chewing and no chewing, we examined the effect of aging on brain regional activity during chewing in young adult, middle-aged, and aged intact humans. In all subjects, chewing resulted in a bilateral increase in the BOLD signals in the sensorimotor cortex, cerebellum, thalamus, supplementary motor area, and insula, and a unilateral increase in the right prefrontal area. In the first three regions, the signal increases were attenuated in an age-dependent manner, whereas, in the right prefrontal area, the converse was seen. The remaining two regions showed no significant differences with ages.We did another fMRI experiment, in which we examined the effect of chewing on the hippocampal activities, by employing a task using photographs containing spatial cognitive function. As a result, the hippocampus in young subjects was strongly activated, but no significant difference was seen between before and after chewing. In contrast, activation in the elderly was quite small in comparison with the young subjects. However, the activation area and the intensity of fMRI signals increased by chewing. Furthermore, according to the results from the recall test, aged subjects showed a significant increase in memory acquisition after chewing. Either combined effect of chewing training and communication during meals or the case of the denture wearers on memory acquisition was also significant. From the above results, we strongly suggest that, in the elderly, occlusal or masticatory stimulus causes an enhancement in hippocampus-dependent memory acquisition.

这个项目的目标是阐明咀嚼器官和包括海马体在内的大脑皮层之间的串扰机制(S)。特别是通过功能磁共振成像(FMRI)和行为科学，重点研究了咬合或咀嚼刺激对老年人记忆过程的预防作用。在第一个实验中，在有节奏的嚼口香糖和不嚼口香糖的循环中使用fMRI，我们研究了年龄对年轻成人、中年和老年完整人类咀嚼过程中大脑区域活动的影响。在所有受试者中，咀嚼导致双侧感觉运动皮质、小脑、丘脑、辅助运动区和脑岛的BOLD信号增加，右侧前额叶区域单侧增加。在前三个区域，信号增加以年龄依赖的方式减弱，而在右侧前额叶区域，则相反。剩下的两个区域没有明显的年龄差异。我们做了另一个功能磁共振实验，通过使用包含空间认知功能的照片进行任务，考察了咀嚼对海马体活动的影响。结果，年轻受试者的海马体被强烈激活，但咀嚼前后没有显著差异。相比之下，与年轻受试者相比，老年人的激活程度相当低。然而，咀嚼增加了fMRI信号的激活面积和强度。此外，根据回忆测试的结果，老年受试者在咀嚼后记忆获得显著增加。无论是咀嚼训练和就餐时的交流，还是假牙佩戴者对记忆获得的综合影响也是显着的。从上述结果中，我们强烈地认为，在老年人中，咬合或咀嚼刺激导致海马区依赖记忆获得的增强。

项目成果

期刊论文数量（16）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

ensitivity of serotonin synthesis to synthesis inhibitor GTP cyclohydrolase I in sensesenceaccelerated mouse-prone inbred strain

sensesenceaccelerated 小鼠近交系中血清素合成对合成抑制剂 GTP 环化水解酶 I 的敏感性

DOI：
发表时间：
2005
期刊：
Acta Histochemica et Cytochemica 38
影响因子：
0
作者：
Higashino F;Aoyagi M;Shindoh M et al.;T.Sato;Karasawa N;T.Sato et al.;Tomonori Sato;Karasawa N;Nakamura H;Kubo K;T.Taniguchi;M.Takahashi;力石秀実;Kato H;T.Taniguchi et al.;Sasaguri K;M.Takahashi et al.;Karasawa N et al.;SKarasawa N et al.
通讯作者：
SKarasawa N et al.

Skull base metastasis from hepatocellular carcinoma revealed by cranial nerve palsy : reports of two cases

颅神经麻痹揭示肝细胞癌颅底转移二例报告

DOI：
发表时间：
2005
期刊：
European Jouranl of Radiology Extra 54
影响因子：
0
作者：
Higashino F;Aoyagi M;Shindoh M et al.;T.Sato;Karasawa N;T.Sato et al.;Tomonori Sato;Karasawa N;Nakamura H;Kubo K;T.Taniguchi;M.Takahashi;力石秀実;Kato H
通讯作者：
Kato H

Ventral lateral geniculate nucleus projects to dorsal lateral geniculate nucleus in the cat

猫的腹侧膝状体核投射到背侧膝状体核

DOI：
发表时间：
2005
期刊：
Neuroreport 16
影响因子：
0
作者：
Higashino F;Aoyagi M;Shindoh M et al.;T.Sato;Karasawa N;T.Sato et al.;Tomonori Sato;Karasawa N;Nakamura H
通讯作者：
Nakamura H

歯周病と全身の健康を考える(分担)

关于牙周病与全身健康的思考（分享）