Mastication-related and aginf-associated genomic events in brain

为了研究咀嚼相关和衰老相关的大脑基因组变化，我们研究了咀嚼功能受损对酸性成纤维细胞生长因子（aFGF）、脑分裂神经因子（BDNF）和c-fos？在衰老加速小鼠（SAM）的大脑中发现了一种即时早期基因，SAM是人类老年痴呆症的动物模型。不同的咀嚼方式对全脑aFGF和BDNF的表达无明显影响。然而，咀嚼功能受损导致海马c-fos表达减少。其中，CA1子区影响最大，其次是CA3子区，最后是齿状回。此外，咀嚼功能受损的小白鼠在Morris水迷宫中的学习能力明显低于正常小白鼠。这些结果表明，咀嚼功能受损可能会导致与年龄相关的海马活动减少，这与记忆障碍有关。

In order to study to mastication-related and aging-associated genomic changes in brain, we investigated the effect of impaired mastication on expression of acidic fibroblast growth factor (aFGF), brain-devided nerve factor (BDNF) and c-fos? an immediate-early gene, in brain of a senescence-accelerated mouse (SAM), an animal model of human senile dementia. When different mastications gave to SAM,no apparent effect on expression of aFGF and BDNF was observed throughout the brain. However, impaired mastication induced a decrease in hippocampal c-fos expression. , the greatest effect being found in the CA1 subfield, followed by the CA3 subfield, then the dentate gyrus. Furthermore, in SAM with impaired mastication, the learning ability in the Morris water maze was significantly decreased compared with that in the intact SAM.These results suggest that impaired mastication may cause the age-related reduction in hippocampal activity, linked to impairment of memory.