Mastication-related and aginf-associated genomic events in brain

大脑中咀嚼相关和 aginf 相关的基因组事件

• 批准号: 08835009
• 负责人: ONOZUKA Minoru
• 金额: $ 1.34万
• 依托单位: Gifu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08835009/
• 关键词: Senile dementia; Aging; Mastication; FGF; Genes; Brain; SAM

In order to study to mastication-related and aging-associated genomic changes in brain, we investigated the effect of impaired mastication on expression of acidic fibroblast growth factor (aFGF), brain-devided nerve factor (BDNF) and c-fos? an immediate-early gene, in brain of a senescence-accelerated mouse (SAM), an animal model of human senile dementia. When different mastications gave to SAM,no apparent effect on expression of aFGF and BDNF was observed throughout the brain. However, impaired mastication induced a decrease in hippocampal c-fos expression. , the greatest effect being found in the CA1 subfield, followed by the CA3 subfield, then the dentate gyrus. Furthermore, in SAM with impaired mastication, the learning ability in the Morris water maze was significantly decreased compared with that in the intact SAM.These results suggest that impaired mastication may cause the age-related reduction in hippocampal activity, linked to impairment of memory.

为了研究咀嚼相关和衰老相关的脑组织基因组变化，本研究观察了咀嚼损伤对酸性成纤维细胞生长因子（aFGF）、脑分神经因子（BDNF）和c-fos基因表达的影响。一种人老年性痴呆的动物模型--加速衰老小鼠（SAM）脑中的即刻早期基因。不同的咀嚼方式对SAM脑内aFGF和BDNF的表达无明显影响。然而，受损的咀嚼诱导海马c-fos表达减少。结果表明，在海马CA 1区，海马CA 3区，齿状回对海马CA 1区的影响最大，其次是齿状回。此外，在SAM的咀嚼受损，在Morris水迷宫中的学习能力显着下降，与在完整的SAM。这些结果表明，咀嚼受损可能会导致与年龄相关的海马活动的减少，与记忆障碍。

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