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Cohort Study on Physical Growth and Development in Triplets and Quadruplets

三胞胎和四胞胎身体生长发育的队列研究

基本信息

批准号：
16390650
负责人：
YOKOYAMA Yoshie
金额：
$ 6.84万
依托单位：
Osaka City University (2007)Okayama University (2004-2006)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2007
项目状态：
已结题

项目摘要

We analyzed the characteristics of weight growth and present the weight growth charts from birth to six years of age in Japanese triplets. The study included 366 mothers and their 1,098 triplet children, who were born between 1978 and 2006. Data were collected through a mailed questionnaire sent to the mothers asking for information recorded in medical records. Birth weight proved to be the strongest contribution on weight of triplets from one to six years of age. In addition, gestational age was also a significant contributing factor to weight from birth to six years of age. Compared to the 50^<th> percentile of the growth standard for the general population of Japan, the weight deficit of the triplets was more than 40% at birth (male, -1.28kg; female, -1.28kg), decreased within the first one year of age, and fluctuated between 4% and 9% until six years of age (male, -1.82kg; female, -1.78kg). In conclusion, triplets have lower birth weight than singletons and in spite of the rapid catch-up growth during first year of life they are behind singletons even in mid-childhood.Moreover, we analyzed a database of medical check-up of infants aged 3 to 6 months between April 2001 and July 2004 in Nishinomiya city in Japan. Exclusive breast-feeding was chosen by 6,680 (43.8%) mothers, mixed-feeding by 4,645 (30.4%) mothers, and bottle-feeding with formula milk only by 3,900 (25.6%) mothers. The rate of exclusive breast-feeding among twins or triplets was significantly lower than among singleton babies: 4.1 % among twins or triplets, and 44.7 % among singletons. Twins and triplets were independently associated with a higher rate of bottle-feeding: the odds ratio indicated that mothers who had twins or triplets were 2.44 times more likely to choose bottle-feeding with formula milk only than those who had singletons.

我们分析了日本三胞胎的体重增长特点，并给出了从出生到6岁的体重增长图表。这项研究包括366名母亲和他们的1,098名三胞胎孩子，他们出生于1978年至2006年之间。数据是通过邮寄问卷收集的，问卷发送给母亲，要求在医疗记录中记录的信息。出生体重被证明是最强的贡献的重量三胞胎从一岁到六岁。此外，胎龄也是影响出生至六岁体重的一个重要因素。与<th>日本一般人群生长标准的50%相比，三胞胎的体重不足在出生时超过40%（男性，-1.28kg;女性，-1.28kg），在第一个1岁内下降，并在4%和9%之间波动，直到6岁（男性，-1.82kg;女性，-1.78kg）。总之，三胞胎有较低的出生体重比单胎，尽管在生命的第一年迅速追赶增长，他们落后于单胎，即使在童年中期。此外，我们分析了2001年4月至2004年7月在日本西宫市的3至6个月的婴儿的医疗检查数据库。6 680名母亲（43.8%）选择纯母乳喂养，4 645名母亲（30.4%）选择混合喂养，3 900名母亲（25.6%）只选择用配方奶奶瓶喂养。双胞胎或三胞胎的纯母乳喂养率明显低于单胞胎：双胞胎或三胞胎为4.1%，单胞胎为44.7%。双胞胎和三胞胎与更高的奶瓶喂养率独立相关：比值比表明，双胞胎或三胞胎的母亲选择奶瓶喂养配方奶粉的可能性是单胞胎母亲的2.44倍。