The tooth movement to the artificial alveolar cleft closed by biological materials of calcium phosphate

牙齿向磷酸钙生物材料封闭人工牙槽裂的移动

• 批准号: 16591979
• 负责人: MATSUI Keiko
• 金额: $ 2.29万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16591979/
• 关键词: biological material; octacalcium phosphate; bone regeneration; artificial bone defect; beagle dog; 人工的顎骨欠損

This study was carried out in order to investigate whether biological materials containing calcium phosphate improve bone regeneration in artificial bone defects in beagles. A scaffold constructed from synthetic Octacalcium phosphate (OCP) and collagen sponge (OCP-Collagen discs: φ9 mm×1 mm) was implanted into three types of bone defect. A critical bone defect (20 mm in diameter) in the dog calvarium, enlarged tooth sockets after extraction of bilateral maxillary third incisors, and an artificial alveolar cleft were prepared.On radiographic examination, the defect in the calvarium implanted with 10 OCP-Collagen discs showed radio-opacity within 6 months, while the control, defects implanted with 10 collagen discs remained radiolucent.The alveolar ridge was flat at the extracted tooth sockets implanted with OCP-Collagen discs, as compared with the concave shape seen in the control side without implantation.Abundant bone regeneration was seen at the artificial alveolar cleft within 4 months after implantation of COP-Collagen discs.The X-ray diffraction (XRD) patterns of implanted OCP-Collagen samples were almost the same as those of intact bone from beagles.The present study suggests that OCP-Collagen composites can improve bone regeneration in medium-sized experimental animals, such as dogs.

本研究旨在探讨含磷酸钙的生物材料是否能促进比格犬人工骨缺损的骨再生。将合成的磷酸八钙（OCP）和胶原海绵（OCP-Collagen discs：φ9 mm×1 mm）制成的支架植入三种类型的骨缺损中。严重的骨缺损（直径为20 mm），拔除双侧上颌第三切牙后扩大的牙槽窝，以及人工牙槽裂。放射学检查显示，植入10个OCP-胶原圆盘的颅骨缺损在6个月内显示射线不透性，而对照组，植入10个胶原圆盘的缺损仍保持放射性，植入OCP-胶原圆盘的拔牙窝处的牙槽嵴平坦，结果表明，COP-胶原盘植入后4个月内，人工牙槽突裂处有大量的骨再生，X线片显示，X射线衍射（XRD）结果表明，OCP-胶原复合材料可促进犬等中型实验动物的骨再生。

项目成果

OCP-Collagen複合体の人工的骨欠損部への応用

OCP-胶原蛋白复合物在人工骨缺损中的应用

• 发表时间: 2006
• 作者: 松井桂子;他5名
• 通讯作者: 他5名

Clinical study on eruption of permanent canines after secondary alveolar bone grafting

• DOI: 10.1597/03-113.1
• 发表时间: 2005-05-01
• 期刊: CLEFT PALATE-CRANIOFACIAL JOURNAL
• 作者: Matsui, K;Echigo, S;Chiba, M
• 通讯作者: Chiba, M

顎裂部への骨移植後に永久犬歯を開窓し萌出誘導した一例

下巴裂口植骨后恒犬开窗萌出的病例。

• 发表时间: 2007
• 期刊: 日本口蓋裂学会雑誌 32
• 作者: 松井桂子;他3名
• 通讯作者: 他3名

The application of octacalcium phosphate (OCP)collagen composites to the artificial bone defects.

磷酸八钙（OCP）胶原复合材料在人工骨缺损中的应用

• 发表时间: 2006
• 作者: Matsui Keiko;ed. al.
• 通讯作者: ed. al.

顎裂部骨移植後の咬合形成-延長ブリッジを応用した一例-

颌裂骨移植后的咬合形成 - 应用延长桥的示例 -

• 发表时间: 2006
• 期刊: 東北大学歯学雑誌 25・1
• 作者: 松井桂子;他3名;松井桂子
• 通讯作者: 松井桂子