Creation of highly functionalized bone regenerative material based on octacalcium phosphate (OCP) collagen composites

基于磷酸八钙（OCP）胶原复合材料创建高功能化骨再生材料

• 批准号: 20300165
• 负责人: KAMAKURA Shinji
• 金额: $ 12.15万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20300165/
• 关键词: 再生医工学材料; 骨再生; バイオマテリアル; 骨代替材料; リン酸カルシウムリン酸オクタカルシウム; 燐酸オクタカルシウム

Bone regenerative properties of various octacalcium phosphate (OCP)?collagen composite (OCP/Col) were investigated. (1) OCP/Col promoted the proliferation and attachment of cells. (2) Bone regeneration by implantation of OCP/Col in small animals was improved by dose-dependent manner of OCP content. The quality of the regenerated bone by implantation of OCP/Col was progressively increased and was compatible to that of normal bone of mechanical properties. (3) In various implantation designs of large animals, sufficient bone regeneration was confirmed by implantation of OCP/Col. These sequential fruitions led to the first clinical trial of OCP/Col implantation in the world.

不同种类磷酸八钙的骨再生性能？胶原复合材料（OCP/Col）。(1)OCP/Col促进细胞增殖和贴壁。(2)OCP/Col植入小动物的骨再生以OCP含量的剂量依赖性方式得到改善。OCP/Col植入后再生骨的质量逐渐提高，且力学性能与正常骨相当。(3)在各种大动物的植入设计中，通过植入OCP/Col证实了足够的骨再生。这些连续的成果导致了世界上第一个OCP/Col植入的临床试验。

项目成果

Bone Regeneration : Growth Factors, Augmentation Procedures and Tissue Engineering Applications.(Nova Science Publishers, Chapter 6: Bone regeneration by octacalcium phosphate (OCP) collagen composites.)

骨再生：生长因子、增强程序和组织工程应用。（Nova Science Publishers，第 6 章：磷酸八钙 (OCP) 胶原复合材料的骨再生。）

• 发表时间: 2010
• 作者: Kamakura S;Anada T;Suzuki O.
• 通讯作者: Suzuki O.

Synthetic Octacalcium Phosphate Augments Bone Regeneration Correlated with Its Content in Collagen Scaffold

• DOI: 10.1089/ten.tea.2008.0141
• 发表时间: 2009-01-01
• 期刊: TISSUE ENGINEERING PART A
• 影响因子: 4.1
• 作者: Kawai, Tadashi;Anada, Takahisa;Suzuki, Osamu
• 通讯作者: Suzuki, Osamu

Reconstruction of Critical-Sized Bone Defect in Dog Skull by Octacalcium Phosphate Combined with Collagen

• DOI: 10.1111/j.1708-8208.2009.00192.x
• 发表时间: 2011-01-01
• 期刊: CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
• 影响因子: 3.6
• 作者: Kawai, Tadashi;Matsui, Keiko;Echigo, Seishi
• 通讯作者: Echigo, Seishi

Mechanical stress-related calvaria bone augmentation by inlayed octacalcium phosphate-collagen implant.

通过镶嵌磷酸八钙胶原蛋白植入物进行机械应力相关的颅盖骨增量。

• 发表时间: 2010
• 期刊: Tissue Eng Part A 16
• 作者: Matsui A;Anada T;Masuda T;Honda Y;Miyatake N;Kawai T;Kamakura S;Echigo S;Suzuki O.
• 通讯作者: Suzuki O.

Quality of Regenerated Bone Enhanced by Implantation of Octacalcium Phosphate-Collagen Composite

• DOI: 10.1089/ten.tec.2009.0212
• 发表时间: 2010-06-01
• 期刊: TISSUE ENGINEERING PART C-METHODS
• 影响因子: 3
• 作者: Masuda, Taisuke;Kawai, Tadashi;Suzuki, Osamu
• 通讯作者: Suzuki, Osamu