Influence of central nervous system on masticate dysfunction from childhood of SAM mice

中枢神经系统对SAM小鼠幼年咀嚼功能障碍的影响

• 批准号: 16592058
• 负责人: IINUMA Mitsuo
• 金额: $ 2.16万
• 依托单位: Asahi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16592058/
• 关键词: Senessence accererated mice; masticatory dysfunction; spatial recognition; fos-positive cells; neurons cells; pyramidal cells; hippocampus; 咬合挙上; 神経細胞; 加齢変化; 経管栄養飼育; 脳幹; 刺激; 認知症; Morris水迷路テスト; Fos陽性細胞数

To investigate the influence of masticatory dysfunction(tube feeding) on the hippocampus, it was conducted an experiment using juvenile (15-week-old after birth) and elderly (35-week-old after birth) Senessence accererated mice (SAMP1). As a behavioral investigation, Morris' water maze test was conducted from 8 days after cube feeding were started. As morphological investigations, the numbers of fos-positive cell, which were linked to the water maze test in the hippocampus, neurons cell and pyramidal cell in the hippocampus were measured after Morris' water maze test.As results in elderly mice acclimated by tube feeding, spatial recognition was reduced, and the number of fos-positive cells, neurons cells and pyramidal cells in the hippocampus was decreased, but not in the juvenile mice.The results of these animal experiments suggest that masticatory dysfunction (tube feeding) decreases information input into the hippocampus, reducing spatial recognition and accelerating the process of aging.

为了研究咀嚼功能障碍（管饲）对海马的影响，使用青少年（出生后15周龄）和老年人（出生后35周龄）Senessence增强小鼠（SAMP 1）进行了实验。作为行为学研究，从开始喂食立方体后第8天开始进行Morris水迷宫测试。作为形态学研究，在Morris水迷宫实验后，测定了海马内与水迷宫实验相关的fos阳性细胞数、海马神经元细胞数和锥体细胞数，结果表明，管饲习服后的老年小鼠空间识别能力下降，海马内fos阳性细胞数、神经元细胞数和锥体细胞数减少，这些动物实验的结果表明，咀嚼功能障碍（管饲）减少了输入海马的信息，降低了空间识别能力，加速了衰老过程。

项目成果

Influence of tube feeding on spatial memory and the number of hippocampus pyramidal cells in SAMP1 mice

管饲对SAMP1小鼠空间记忆及海马锥体细胞数量的影响

• 发表时间: 2007
• 期刊: 岐歯誌 33(3)
• 作者: Nishida M.

Influence of tube feeding on hippocampus in SAMP1 mice

管饲对SAMP1小鼠海马的影响

• 发表时间: 2007
• 作者: Nishida M.;M.Iinuma
• 通讯作者: M.Iinuma

Influence of tube feeding on hippocampus SAMP1mice

管饲对SAMP1小鼠海马的影响

• 发表时间: 2007
• 作者: Nishida M.;M.Iinuma;Iinuma M.
• 通讯作者: Iinuma M.

Effects of tube feeding on hippocampal in SAMP1mice

管饲对 SAMP1 小鼠海马的影响

• 发表时间: 2005
• 作者: Nishida M.;M.Iinuma;Iinuma M.;Mineda Y
• 通讯作者: Mineda Y