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Effects of chronic stress of early tooth extraction on hippocampus in senescence-accelerated mice

早期拔牙慢性应激对加速衰老小鼠海马的影响

基本信息

批准号：
20592420
负责人：
IINUMA Mitsuo
金额：
$ 2.91万
依托单位：
Asahi University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2011
项目状态：
已结题

项目摘要

This evaluations were whether long-term tooth loss induces functional and morphologic changes in the hippocampus in senescence-accelerated mice(SAMP8). The teeth were extracted at an early age.The results were as follow.1, Plasma corticosterone concentration as a stressor was significantly higher in old or mature mice with long-term tooth loss groups than in the age-matched controls.2, In the Morris water maze learning and spatial memory trials was significantly slower in the mature or old long-term tooth loss groups compared with the age-matched controls.3, The number of hippocampal neurons was significantly reduced in the CA3 region of the hippocampus in the mature and old long-term tooth loss groups compared with their age-matched controls, but there was no significant difference in the CA1 or dentate gyrus(DG) region between the mature or old long-term tooth loss groups and their age-matched controls.4, The number of GFAP-positive cells was significantly higher in the CA3 region of the hippocampus in the mature or old long-term tooth loss groups compared with age-matched controls. However, no significant difference was observed in the CA1 or DG of the hippocampus in the mature or old mice.5, The number of BrdU-positive cells was significantly increased in the DG of the hippocampus in the mature or old long-term tooth loss groups compared with age-matched controls.6, In the hippocampus, note the significant decrease in synaptopysin expression in the mature or old long-term tooth loss groups compared with age-matched controls.The findings indicated that long-term tooth loss enhances the effects of aging on the hippocampus in mice.

该评估是长期牙齿缺失是否会引起加速衰老小鼠（SAMP8）海马体的功能和形态变化。结果如下：1、老年或成熟长期牙齿缺失组小鼠的血浆皮质酮浓度作为应激源显着高于年龄匹配的对照组。2、在Morris水迷宫学习和空间记忆试验中，成熟或老年长期牙齿缺失组的学习和空间记忆试验明显慢于年龄匹配的对照组。3、海马神经元数量显着减慢。成熟组和老年长期失牙组海马CA3区较同龄对照组减少,但CA1区或齿状回(DG)区与年龄匹配对照组无显着差异。 4、成熟组和老年长期失牙组海马CA3区GFAP阳性细胞数显着高于同龄对照组。年龄匹配的控制。然而，成熟或老年小鼠海马CA1或DG未观察到显着差异。 5、成熟或老年长期失牙组海马DG中BrdU阳性细胞数量与年龄匹配对照组相比显着增加。 6、在成熟或老年长期失牙组海马中，与年龄匹配对照组相比，海马突触蛋白表达显着下降研究结果表明，长期牙齿脱落会增强小鼠海马体衰老的影响。