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Destruction of the biological clock system by environmental contaminants : Crosstalk between heme, NO, protein synthesis and clock genes

Destruction of the biological clock system by environmental contaminants : Crosstalk between heme, NO, protein synthesis and clock genes
环境污染物对生物钟系统的破坏:血红素、NO、蛋白质合成和生物钟基因之间的串扰
批准号:
17101002
负责人:
SHIMIZU Toru
金额:
$71.14万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009

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中文摘要
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英文摘要
[1] Molecular mechanisms of NO- and heme-sensing of heme-regulated kinase (HRI) and heme-regulated transcriptional factors were elucidated and mercury was found to break the heme-protein interactions.; [2] Thiolate and α-lipoic acid remedied depressive behavior of mice induced by methyl-mercury.; [3] Gas-recognition sites and molecular mechanism of gas-induced catalytic enhancement of the heme-regulated gas-sensor enzymes were elucidated.
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Role of Phe113 at the distal side of the heme domain of an oxygen-sensor(Ec DOS)in the characterization of the heme environment
氧传感器 (Ec DOS) 血红素域远端 Phe113 在血红素环境表征中的作用
DOI: --
发表时间: 2009
期刊: Journal of Inorganic Biochemistry 103
影响因子: --
作者: [Ito, Shinya, Araki, Yasuyuki, Tanaka, Atsunari, Igarashi, Jotaro, Wada, Takehiko, Shimizu, Toru]
通讯作者: Toru
Site-directed mutagenesis study to identify the heme binding site…
定点诱变研究以确定血红素结合位点......
DOI: --
发表时间: 2007
期刊:
影响因子: --
作者: [村瀬元彦, 他]
通讯作者:
Characterization of Cry, an FAD-binding protein associated with…
Cry 的表征,一种与……相关的 FAD 结合蛋白
DOI: --
发表时间: 2007
期刊:
影响因子: --
作者: [石川静, 他]
通讯作者:
DOI: 10.1074/jbc.m701920200
发表时间: 2007-07-20
期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子: 4.8
作者: [Tanaka, Atsunari, Takahashi, Hiroto, Shimizu, Toru]
通讯作者: Shimizu, Toru
64
    An Annotated catalogue of Yi(Lolo) manuscripts in Academia Sinica, Taiwan
    • 批准号:
      21520432
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.08万
    • 财政年份:
      2009
    • 负责人:
      SHIMIZU Toru
    • 依托单位:
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    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $24.29万
    • 财政年份:
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    Construction of Environmental Biremediation Enzymes Whose Catalysis is Regulated by Light and Molecular Switches
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      13558069
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      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $8.13万
    • 财政年份:
      2001
    • 负责人:
      SHIMIZU Toru
    • 依托单位:
    TOXIN-DIRECTED MOLECULAR CONVERSION SYSTEM WITH YEAST HARBORING HIGHLY ACTIVATED P450 ENZYME BY ARTIFICIAL MUTAGENESIS
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      09480130
    • 项目类别:
      Grant-in-Aid for Scientific Research (B).
    • 资助金额:
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    • 财政年份:
      1997
    • 负责人:
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    • 依托单位:
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