Destruction of the biological clock system by environmental contaminants : Crosstalk between heme, NO, protein synthesis and clock genes
Destruction of the biological clock system by environmental contaminants : Crosstalk between heme, NO, protein synthesis and clock genes
批准号:
17101002
负责人:
SHIMIZU Toru
金额:
$71.14万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (S)
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009
中文摘要
点击翻译按钮获取中文摘要
英文摘要
[1] Molecular mechanisms of NO- and heme-sensing of heme-regulated kinase (HRI) and heme-regulated transcriptional factors were elucidated and mercury was found to break the heme-protein interactions.; [2] Thiolate and α-lipoic acid remedied depressive behavior of mice induced by methyl-mercury.; [3] Gas-recognition sites and molecular mechanism of gas-induced catalytic enhancement of the heme-regulated gas-sensor enzymes were elucidated.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Role of Phe113 at the distal side of the heme domain of an oxygen-sensor(Ec DOS)in the characterization of the heme environment
氧传感器 (Ec DOS) 血红素域远端 Phe113 在血红素环境表征中的作用
DOI:
--
发表时间:
2009
期刊:
Journal of Inorganic Biochemistry 103
影响因子:
--
作者:
[Ito, Shinya, Araki, Yasuyuki, Tanaka, Atsunari, Igarashi, Jotaro, Wada, Takehiko, Shimizu, Toru]
通讯作者:
Toru
Site-directed mutagenesis study to identify the heme binding site…
定点诱变研究以确定血红素结合位点......
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[村瀬元彦, 他]
通讯作者:
他
Characterization of Cry, an FAD-binding protein associated with…
Cry 的表征,一种与……相关的 FAD 结合蛋白
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[石川静, 他]
通讯作者:
他
DOI:
10.1074/jbc.m701920200
发表时间:
2007-07-20
期刊:
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子:
4.8
作者:
[Tanaka, Atsunari, Takahashi, Hiroto, Shimizu, Toru]
通讯作者:
Shimizu, Toru
DOI:
10.1111/j.1742-4658.2005.04828.x
发表时间:
2005-08-01
期刊:
FEBS JOURNAL
影响因子:
5.4
作者:
[Koudo, R, Kurokawa, H, Shimizu, T]
通讯作者:
Shimizu, T
共 64 条
An Annotated catalogue of Yi(Lolo) manuscripts in Academia Sinica, Taiwan
-
批准号:21520432
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.08万
-
财政年份:2009
-
负责人:SHIMIZU Toru
-
依托单位:
Analyses of Porphyria Caused by Environmental Pollutants : Concerted Reaction and Tempo of Heme and Porphyrin Syntheses
-
批准号:14208066
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$24.29万
-
财政年份:2002
-
负责人:SHIMIZU Toru
-
依托单位:
Construction of Environmental Biremediation Enzymes Whose Catalysis is Regulated by Light and Molecular Switches
-
批准号:13558069
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.13万
-
财政年份:2001
-
负责人:SHIMIZU Toru
-
依托单位:
TOXIN-DIRECTED MOLECULAR CONVERSION SYSTEM WITH YEAST HARBORING HIGHLY ACTIVATED P450 ENZYME BY ARTIFICIAL MUTAGENESIS
-
批准号:09480130
-
项目类别:Grant-in-Aid for Scientific Research (B).
-
资助金额:$8.13万
-
财政年份:1997
-
负责人:SHIMIZU Toru
-
依托单位:
Development and Characterization of Biotransformation System toward Helogenated Compounds with Yeast
-
批准号:07558083
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$11.52万
-
财政年份:1995
-
负责人:SHIMIZU Toru
-
依托单位:
Structure-Function Relationship of Biodeseigned NO Synthase and Dynamics of NO
-
批准号:07680670
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.41万
-
财政年份:1995
-
负责人:SHIMIZU Toru
-
依托单位:
Reorganization of Rural Communities and Its Influence on the Urban Ethnicity in Iberial and Latin American Tradition
-
批准号:01044051
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$7.23万
-
财政年份:1989
-
负责人:SHIMIZU Toru
-
依托单位:
海外基金