Homology found between the mouse neocortical neurogenesis and drosophila neurogenesis.

小鼠新皮质神经发生和果蝇神经发生之间发现同源性。

• 批准号: 17300106
• 负责人: TAMAMAKI Nobuaki
• 金额: $ 9.73万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17300106/
• 关键词: drosophila; neurogenesis; neocortex; neuron progenitor; intermediate progenitor; GABA神経細胞; 興奮性神経細胞; 希突起膠細胞

The SVZ has been recognized as a possible source of neocortical neurons. We speculated that neurogenesis in the SVZ is a mechanism underlying the neocortical expansion in primate evolution. We found a subset of the progenitor cells within the SVZ of the mouse neocortex can be molecularly defined by Cre recombinase expression under control of the NEX/Math2 locus, a neuronal basic helix-loop-helix (bHLH) gene. NEX-positive secondary progenitors are generated by VZ cells, move into the SVZ, and undergo asymmetrical and symmetrical cell division. The asymmetrical cell division like budding produced tertiary progenitors, and the symmetrical cell divisions expanded secondary progenitor pool. Finally the symmetrical cell division of the tertiary progenitors produced a fraction of the pyramidal neurons in the upper cortical layers.

SVZ已被认为是新皮质神经元的一个可能来源。我们推测，SVZ的神经发生是灵长类进化中新皮质扩张的一种机制。我们发现，小鼠新皮质SVZ内的一部分祖细胞可以由NEX/Math2基因(神经元基本螺旋-环-螺旋(BHLH)基因)控制下的Cre重组酶表达来分子定义。NEX阳性的次级祖细胞由VZ细胞产生，进入SVZ，经历不对称和对称的细胞分裂。萌芽状的细胞分裂不对称产生三级祖细胞，对称的细胞分裂扩大了二次祖细胞池。最后，第三代祖细胞的对称性细胞分裂产生了上层皮质中的一小部分锥体神经元。

项目成果

Neurogenesis in the ependymal layer of the adult rat 3rd ventricle

• DOI: 10.1016/j.expneurol.2004.12.021
• 发表时间: 2005-04-01
• 期刊: EXPERIMENTAL NEUROLOGY
• 影响因子: 5.3
• 作者: Xu, Y;Tamamaki, N;Ide, C
• 通讯作者: Ide, C

Dorsally derived netrin 1 provides an inhibitory cue and elaborates the ;waiting period' for primary sensory axons

背侧衍生的 netrin 1 提供抑制信号并详细说明初级感觉轴突的“等待期”

• 发表时间: 2006
• 期刊: Development 133
• 作者: Higo S;Udaka N;Tamamaki N;Mami Matsuo-Takasaki;Higo et al.;Watanabe et al.
• 通讯作者: Watanabe et al.

Dorsally derived netrin 1 provides an inhibitory cue and elaborates the ; waiting period' for primary sensory axons

背侧衍生的 netrin 1 提供抑制信号并详细阐述；

• 发表时间: 2006
• 期刊: Development 133
• 作者: Nakamura K;Yamashita Y;Tamamaki N;Katoh H;Kaneko T;Negishi M;Watanabe et al.
• 通讯作者: Watanabe et al.

In vivo function of Rnd2 in the development of neocortical pyramidal neurons

• DOI: 10.1016/j.neures.2005.10.008
• 发表时间: 2006-02
• 期刊: Neuroscience Research
• 影响因子: 2.9
• 作者: K. Nakamura;Y. Yamashita;N. Tamamaki;H. Katoh;T. Kaneko;M. Negishi

Origin of the neocortical subependymal cells speculated by Emx1 and GAD67 expression.

• DOI: 10.1093/chemse/bjh139
• 发表时间: 2005
• 期刊: Chemical senses
• 影响因子: 3.5
• 作者: N. Tamamaki