Homology found between the mouse neocortical neurogenesis and drosophila neurogenesis.

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The SVZ has been recognized as a possible source of neocortical neurons. We speculated that neurogenesis in the SVZ is a mechanism underlying the neocortical expansion in primate evolution. We found a subset of the progenitor cells within the SVZ of the mouse neocortex can be molecularly defined by Cre recombinase expression under control of the NEX/Math2 locus, a neuronal basic helix-loop-helix (bHLH) gene. NEX-positive secondary progenitors are generated by VZ cells, move into the SVZ, and undergo asymmetrical and symmetrical cell division. The asymmetrical cell division like budding produced tertiary progenitors, and the symmetrical cell divisions expanded secondary progenitor pool. Finally the symmetrical cell division of the tertiary progenitors produced a fraction of the pyramidal neurons in the upper cortical layers.