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Development of fluid-structure interaction simulator and its evaluation by in vitro measurement

流固耦合模拟器的研制及其体外测量评价

基本信息

批准号：
17360076
负责人：
OSHIMA Marie
金额：
$ 9.54万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

项目摘要

We developed an integrated cardiovascular system simulator and conducted image-based modeling and Fluid-Structure Interaction (FSI) Finite Element analysis (FEA) of human middle cerebral arterial aneurysm (MCAA). The computational model of MCAA is constructed from CT images.1)Development of cardiovascular system simulatorThe fluid is assumed to be laminar, Newtonian, viscous, and incompressible to represent blood. The arterial wall is assumed to be hyperelastic, isotropic, incompressible, and homogeneous. Fluid-structure coupling is performed by strong coupling method.The simulation result suggests that the hydrodynamic force of blood flow on aneurysm wall is not small and FSI analysis should be conducted for accurate analysis of cerebral aneurysm.We also structured peripheral vessel network based on anatomical knowledge, and applied the boundary condition taking account of the effects of peripheral vessel network to 3D hemodynamic simulation. 1D analysis of the peripheral vessels is a … More pplied as the boundary condition for 3D analysis, and 0D model as that for 1D analysis. For 0D model, structured tree impedance model is employed. The peripheral resistance, compliance, and impedance of vessel are treated by 1D analysis and 0D model.As a result, the present method shows a significant difference in flow rate of each artery and improvement in flow distribution and direction. Particularly, for the case with occlusion, collateral flow in the arterial circle of Willis is observed.2)Experiment using in vitro model with realistic vessel geometryWe made the in vitro model using rapid prototyping system and lost model technique. The model has realistic vessel geometry with cerebral aneurysm at bifurcation area. The measurement of flow structure in the aneurysm was conducted under the steady inflow conditions. The streamline is calculated form velocity data, and the flow structure along the aneurysm wall was observed. As the result of calculating the WSS (wall shear stress) using velocity data and geometry data, high WSS area was observed in the aneurysm.3) Comparison between numerical analysis and experimental resultWe compared experimental result to numerical analysis using the vessel geometry of in vitro model at same conditions. The velocity distribution and streamline pattern were similar, but high WSS was appeared at different area. Less

我们开发了一个集成的心血管系统模拟器，并进行了基于图像的建模和流固耦合（FSI）有限元分析（FEA）的人大脑中动脉瘤（MCAA）。1）心血管系统模拟器的研制假设血液是层流、牛顿、粘性、不可压缩的流体。假设动脉壁是超弹性的、各向同性的、不可压缩的和均匀的。采用强耦合方法进行流固耦合，仿真结果表明，血流对动脉瘤壁的流体动力作用不小，要准确分析脑动脉瘤，必须进行流固耦合分析;基于解剖学知识构建外周血管网络，将考虑外周血管网络影响的边界条件应用于三维血流动力学仿真。外周血管的1D分析是 ...更多信息作为三维分析的边界条件，作为一维分析的边界条件。对于0 D模型，采用结构化树阻抗模型。采用一维分析和一维模型对血管的外周阻力、顺应性和阻抗进行处理，结果显示各动脉的流速差异显著，改善了血流的分布和流向。特别是在闭塞的情况下，观察到Willis动脉环内的侧支循环。2）真实血管形态的离体模型实验采用快速成型系统和失模技术制作了Willis动脉环的离体模型。该模型具有逼真的血管几何形状，分叉区域有脑动脉瘤。在稳定流入条件下进行动脉瘤内流动结构的测量。根据速度数据计算流线，观察了沿着动脉瘤壁的流动结构。利用速度数据和几何数据计算壁面切应力（WSS），结果表明，在血管壁中存在高WSS区域。3）数值分析与实验结果的比较在相同条件下，利用离体血管模型的几何形状，将实验结果与数值分析结果进行比较。速度分布和流线形态相似，但不同区域出现高WSS。少