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IN VITRO MEASUREMENT OF BINDING OF SELF AND ANTIGENIC PEPTIDES TO MHC MOLECULES

IN VITRO MEASUREMENT OF BINDING OF SELF AND ANTIGENIC PEPTIDES TO MHC MOLECULES
自身肽和抗原肽与 MHC 分子结合的体外测量
批准号：
3790855
负责人：
D H MARGULIES
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3790855
关键词：
MHC class I antigen X ray crystallography antigens autoantigens chemical binding intermolecular interaction mathematical model peptides

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中文摘要
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英文摘要
The focus of this laboratory has been the MHC class I molecule, classically considered a molecular heterodimer consisting of a 46 kd polymorphic heavy chain, exemplified by the murine H-2K, D, and L molecules (analogous to the human HLA-A, -B, and -C molecules), that is non-covalently assembled with the 12 kd monomorphic light chain, beta2-microglobulin. Our objectives in this project have been to examine the interaction of self and antigenic peptides to the MHC class I molecule using several different systems and to evaluate these interactions in three dimensional computer modeling studies based on crystallographic MHC structures.
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IN VITRO MEASUREMENT OF BINDING OF SELF AND ANTIGENIC PEPTIDES TO MHC MOLECULES
MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION
MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION
MOLECULAR GENETIC ANALYSIS OF LYMPHOCYTE FUNCTION
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