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Interactions between airway smooth murle cells and inflammatory cells in the pathogenesis of asthma

哮喘发病机制中气道平滑肌细胞与炎症细胞的相互作用

基本信息

批准号：
17390242
负责人：
TAKIZAWA Hajime
金额：
$ 10.5万
依托单位：
Teikyo University (2006-2007)The University of Tokyo (2005)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

It has been suggested that airway smooth muscle cells play important roles in the pathogenesis of asthma, but precise mechanisms remain unclear W efocused on the interactions between these structural cells and inflammatory cells such as T cells, mast cells and eosinophils Human airway smooth muscle cells express and release stem cell factor, TGF beat family molecules and and versican. These factors are believed to be chemotactic for mast cells and also be involved in airway wall remodling.IL-9, a class of Th2 type cytokine, is a potent inducer acting on airway smooth muscle cells.Airway structural cells are once believed to be terminally differentiated cells, but recent reports strongly suggest that even these cells may change in to other type of cells. We demonstrated that human epithelial cells showed a distinct epithelial mesenchymal transition (EMT) upon stimulation of TGFbeta. These changes were induced by TNFalpha. It was suggested that dynamic interactions between airway structural cells and inflammatory cells via cytokines and growth factors play important roles in the regulation of airway remodeling in the pathogenesis of asthma. These new finding may highlight a way to develop novel type of anti-asthma drugs preventing remodeling, an irreversible airway change

气道平滑肌细胞在哮喘的发病机制中起重要作用，但其确切机制尚不清楚，我们主要研究这些结构细胞与T细胞、肥大细胞和嗜酸性粒细胞等炎症细胞的相互作用。IL-9是一类Th 2型细胞因子，是一种作用于气道平滑肌细胞的强诱导因子，气道结构细胞曾被认为是终末分化细胞，但最近的研究表明，这些细胞也可能向其他类型的细胞转化。我们证明，人类上皮细胞显示出一个独特的上皮间质转化（EMT）刺激TGF β。这些变化由TNF α诱导。提示气道结构细胞与炎症细胞通过细胞因子和生长因子的动态相互作用在哮喘气道重塑的调控中起重要作用。这些新发现可能为开发新型抗哮喘药物提供了一种方法，可以防止气道重塑，这是一种不可逆的气道变化

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Methotrexate induces proinflammatory cytokines production by human bronchial and alveolar epithelial cells

甲氨蝶呤诱导人支气管和肺泡上皮细胞产生促炎细胞因子

DOI：
发表时间：
2006
期刊：
影响因子：
0
作者：
Yamauchi Y;et. al.
通讯作者：
et. al.

Airway inflammatory responses to oxidative stress induced by prolonged low-dose diesel exhaust particle exposure from birth differ between mouse BALB/C and C57BL/6 strains

DOI：
10.1080/01902140701884406
发表时间：
2008-03-01
期刊：
EXPERIMENTAL LUNG RESEARCH
影响因子：
1.7
作者：
Li, Ying-Ji;Kawada, Tomoyuki;Kohyama, Tadashi
通讯作者：
Kohyama, Tadashi

TGF-beta1 and serum both stimulate contraction but differentially affect apoptosis in 3D collagen gels.

TGF-β1 和血清均刺激收缩，但对 3D 胶原凝胶中的细胞凋亡影响不同。

DOI：
发表时间：
2006
期刊：
Respir Res 2;6:
影响因子：
0
作者：
Matsumoto;A.;Hiramatsu;K.;Li;Y.;Azuma;A.;Kudoh;S.;Takizawa;H.;Sugawara;I;Kobayashi T et al.;Fang Q et al.;幸山正;Kobayashi T et al.
通讯作者：
Kobayashi T et al.

Repeated exposure to low-dose diesel exhaust after allergen challenge exaggerates asthmatic responses in mice