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Clinicopathological study of pediatric gliomas with extensive myxoid change

伴有广泛粘液样改变的儿童胶质瘤的临床病理学研究

基本信息

批准号：
17500220
负责人：
HIRATO Junko
金额：
$ 1.84万
依托单位：
Gunma University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17500220/
关键词：
Glioma Childhood Myxoid matrix Histopathology Immunohistochemistry Oncogene 臨床病理学

项目摘要

Ten cases with gliomas with extensive myxoid change were selected from files of brain tumors diagnosed at Gunma University Hospital and cases sent to the author for consultation, and were examined. Patient age of nine cases ranged between 1 and 16 years and 24-old year patient was added. All tumors except a cerebellar tumor arose in supratentorial region. Three cases had developed acute lymphoblastic leukemia(ALL) in their past history.Tumor tissues showed microcystic change, angiocentric pattern, and sparsely diffuse pattern with extensive myxoid change. Tumor cells appeared to have a tendency of aggregating to perivascular space. The tumors were divided into low-grade and high-grade groups from the aspects of anaplasia and proliferation ability. Five of seven high-grade tumors included small primitive cell component One of them consisted of only small primitive cells that were positive for synaptophysin, and showed high proliferation ability. It was histologically consistent with pri … More mitive neuroectodermal tumor (PNET). In addition to primitive cells, two cases were composed of differentiated astrocytes without anaplasia, and other two cases had diffusely proliferating glioma component showing anaplasia. Two cases without primitive component were similar to high grade astrocytoma, but the tumor cells hardly expressed glial fibrillary acidic protein (GFAP), but did vimentin. Other three cases were classified as low-grade glioma, including pilomyxoid astrocytoma, astrocytic tumor negative for GFAP, and oligodendroglioma-like tumor.Most myxoid gliomas were high-grade. In addition, they often harbored small primitive cell component Some of them were considered to be a variant of glioblastoma. Small primitive cells frequently expressed Olig2 or 5-100 protein. The finding was different from that of conventional PNET. APNET-like tumor did not overexpress EGFR or p53.Three cases developed myxoid glioma after remission of ALL by chemotherapy and/or radiotherapy. It is possible that myxoid gliomas may occur as secondary tumor or radiation-induced tumor. Less

从群马大学医院诊断的脑肿瘤档案和送作者咨询的病例中，选取10例伴有广泛粘液样改变的胶质瘤病例进行检查。 9例患者年龄在1岁至16岁之间，并增加了24岁患者。除小脑肿瘤外，所有肿瘤均发生于幕上区域。 3例既往有急性淋巴细胞白血病(ALL)史，肿瘤组织呈微囊性变、血管中心型、稀疏弥漫型伴广泛粘液样变。肿瘤细胞似乎有聚集到血管周围空间的倾向。从退行性和增殖能力方面将肿瘤分为低级别组和高级别组。七个高级肿瘤中的五个包含小原始细胞成分，其中一个仅由突触素阳性的小原始细胞组成，并显示出高增殖能力。它在组织学上与原发性神经外胚层肿瘤（PNET）一致。除原始细胞外，2例由分化的星形胶质细胞组成，无退行性变，另外2例有弥漫性增殖的胶质瘤成分，表现为退行性变。两例无原始成分，与高级别星形细胞瘤相似，但肿瘤细胞几乎不表达胶质纤维酸性蛋白（GFAP），但表达波形蛋白。另外3例为低级别胶质瘤，包括毛粘液样星形细胞瘤、GFAP阴性星形细胞瘤和少突胶质细胞瘤样肿瘤。大多数粘液样胶质瘤为高级别胶质瘤。此外，它们通常含有小的原始细胞成分，其中一些被认为是胶质母细胞瘤的变体。小原始细胞经常表达 Olig2 或 5-100 蛋白。这一发现与传统 PNET 的发现不同。 APNET样肿瘤不过度表达EGFR或p53。3例经化疗和/或放疗缓解ALL后发展为粘液样胶质瘤。粘液样神经胶质瘤可能作为继发性肿瘤或放射诱发的肿瘤而发生。较少的

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

病理診断に役立つ免疫組織化学の新しいマーカー脳腫瘍の診断への応用

有助于病理诊断的新型免疫组化标记物在脑肿瘤诊断中的应用

DOI：
发表时间：
2007
期刊：
診断病理 24
影响因子：
0
作者：
Koitabashi M;Kanazawa T;Tamura K;Tsukada S;Suzuki M;Morikawa A;Ogawa C;Hirado J.;Tomomi Miyallaga;Nishihira Y;Tosaka M;平戸純子;Junko Hirato;平戸純子;平戸純子;平戸純子
通讯作者：
平戸純子

An eight-year survivor with multiple brain metastases of non-small lung cancer: an autopsy case

非小细胞肺癌多发脑转移的八年幸存者：尸检案例

DOI：
发表时间：
2006
期刊：
Anticancer research 26
影响因子：
0
作者：
Tosaka M;Sato N;Hirato J;Fujimaki H;Yamaguchi R;Kohga H;Hashimoto K;Yamada M;Mori M;Saito N;Yoshimoto Y.;Hirato J;Hirato J;Hirato J.;Hirato J;Hirato J;Matsuda H;Kawamura H
通讯作者：
Kawamura H

Processin diagnosis of brain tumors

脑肿瘤的流程诊断