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Anti-stress effects of plants used in Japanese traditional festivals and development of the anti-stress aromatic agents of the taste of the Japanese

日本传统节日植物的抗应激作用及日本人口味的抗应激芳香剂的开发

基本信息

批准号：
17500484
负责人：
KOBAYASHI Yoshinori
金额：
$ 2.4万
依托单位：
Kitasato University (2007)Nigata University of Phermacy and Applied Life Sciences (2005-2006)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

Anti-stress effects of the aromatic plants used for Japanese traditional seasonal events were evaluated. Essential oils were obtained from Atractylodes rhizomes, pine leafs, white peach blossoms, peach kernels, mugwort leafs, calamus rhizomes, bamboo leafs, chrysanthemum flowers and Evodia fruits. The sedative effects of these essential oils were evaluated in a mice open field test. The exposure of a mouse to a novel environment induces exploratory behavior resulting in an increase in spontaneous motor activity. The reduction of the spontaneous motor activity was translated as the sedative effects, or anti-stress effects. The essential oils from Atractylodes rhizomes and Evodia fruits showed significant reduction in the spontaneous motor activity. The sedative effect of Evodia fruit's essential oil was comparable to that of lavender flower's essential oil. In addition, the sedative effects of these essential oils disappeared in the experimentally induced anosmic mice. Our data suggest that the fragrance of the Evodia fruits would be useful for relaxation and stress management. The analysis of heart rate variably might be useful to evaluate the anti-stress effects of the fragrance. The variation index of the heart rate R-R interval was the most suitable index to detect the load and liberation of mental stress in human studies. The effects of the intake of coffee and GABA were also observed. Anti-stress effects of the fragrance of Evodia Fruits in mice and human are going to be evaluated in future.

对用于日本传统季节性活动的芳香植物的抗应激效果进行了评价。挥发油是从白术根茎、松叶、白色桃花、桃仁、艾叶、菖蒲根茎、竹叶、菊花和吴萸果实中提取的。这些精油的镇静作用在小鼠旷场试验中进行了评价。将小鼠暴露于新环境诱导探索行为，导致自发运动活动增加。自发运动活动的减少被翻译为镇静作用或抗应激作用。吴茱萸和苍术的挥发油能显著降低小鼠的自发活动。吴茱萸精油的镇静作用与熏衣草花精油相当。此外，这些精油的镇静作用在实验诱导的嗅觉缺失小鼠中消失。我们的数据表明，吴茱萸果实的香味将有助于放松和压力管理。心率变异性分析可用于评价芳香剂的抗应激作用。心率R-R间期变异指数是人体研究中最适合检测精神应激负荷和释放的指标。还观察了咖啡和GABA摄入量的影响。吴茱萸香精对小鼠和人体的抗应激作用有待进一步研究。