权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Regulation of adipocytes differentiation by marine lipids

海洋脂质对脂肪细胞分化的调节

基本信息

批准号：
17580178
负责人：
HOSOKAWA Masashi
金额：
$ 2.41万
依托单位：
Hokkaido University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2007
项目状态：
已结题

项目摘要

Obesity is now recognized as a world wide problem. It is multiple risk factors for the life style-related diseases such as diabetes, hypertension, hyperlipidemia, and cardiovascular disease. Visceral fat accumulation plays crucial roles in the development of these diseases. So, it is important to prevent the life style-related diseases through significantly reducing excess accumulation of visceral fat. Fucoxanthin is a major carotenoid found in edible seaweed such as Undaria pinnatifida and Hijikia fusiformis. Fucoxanthin and its metabolite, fucoxanthinol, inhibited intercellular lipid accumulation and suppressed glycerol-3-phosphate dehydrogenase activity during adipocyte differentiation of 3T3-L1 cells. In addition, in 3T3-L1 cells treated with fucoxanthin and fucoxanthinol, peroxisome proliferators-activated receptor (PPAR_γ), which regulates adipogenic gene expression, was down-regulated in a dose-dependent manner. N-3 Highly unsaturated fatty acid, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), which are major fatty acids in fish oil, also suppressed adipocyte differentiation of 3T3-L1 cells by down regulation PPAR_γ And C/EBP_α. White adipose tissue weight of mice fed fucoxanthin was significantly lower than that of mice fed control diet. Uncoupling protein 1(UCP1), a key molecule for metabolic thermogenesis, was clearly found in WAT of mice fed fucoxanthin. The anti-obesity effect of fucoxanthin was enhanced by the combination with fish oil containing DHA and EPA

肥胖现在被认为是一个世界性问题。它是糖尿病、高血压、高脂血症、心血管疾病等生活方式相关疾病的多重危险因素。内脏脂肪积累在这些疾病的发展中起着至关重要的作用。因此，通过显着减少内脏脂肪的过度积累来预防与生活方式相关的疾病非常重要。岩藻黄质是一种主要的类胡萝卜素，存在于食用海藻中，例如裙带菜和羊栖菜。岩藻黄质及其代谢物岩藻黄质醇在 3T3-L1 细胞的脂肪细胞分化过程中抑制细胞间脂质积累并抑制 3-磷酸甘油脱氢酶活性。此外，在用岩藻黄质和岩藻黄质醇处理的3T3-L1细胞中，调节脂肪形成基因表达的过氧化物酶体增殖物激活受体（PPAR_γ）以剂量依赖性方式下调。 N-3高度不饱和脂肪酸，二十二碳六烯酸（DHA）和二十碳五烯酸（EPA）是鱼油中的主要脂肪酸，也通过下调PPAR_γ和C/EBP_α抑制3T3-L1细胞的脂肪细胞分化。喂食岩藻黄质的小鼠的白色脂肪组织重量显着低于喂食对照饮食的小鼠。解偶联蛋白 1 (UCP1) 是代谢产热的关键分子，在喂食岩藻黄质的小鼠的 WAT 中明显发现。岩藻黄质与含有 DHA 和 EPA 的鱼油结合可增强其抗肥胖作用