Preventive effects of marine carotenoids on life-style-related diseases based on anti-inflammatory effects as molecular targets

以抗炎作用为分子靶标的海洋类胡萝卜素对生活方式相关疾病的预防作用

• 批准号: 20380117
• 负责人: HOSOKAWA Masashi
• 金额: $ 12.4万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20380117/
• 关键词: 食品化学; 分子栄養学; カロテノイド; 抗炎症; サイトカイン; 肥満; 大腸癌; マクロファージ; 脂肪組織; 大腸組織; 大腸; 脂肪細胞; 炎症性腸疾患; アスタキサンチン

Astaxanthin exhibited inhibitory effects on dextran sodium sulfate-induced colitis and inflammatory-related colon carcinogenesis in mice. In colon of the mice fed astaxanthin, mRNA expression levels of inflammatory cytokines such as TNF-α and IL-1β were suppressed through inhibition of NF-κB activation. After feeding for 20 weeks, colonic mucosal ulcers, dysplastic crypts and colonic adenocarcinoma were inhibited by 200 ppm astaxanthin-containing diet. In addition, astaxanthin, pectenolone, alloxanthin and diatoxanthin isolated from marine organisms attenuated excessive mRNA expression of inflammatory cytokines and COX-2 and iNOS in macrophages activated by LPS. On the other hand, dietary 0.2% fucoxanthin markedly suppressed mRNA expression of inflammatory cytokines such as TNF-α and IL-6 to induce insulin resistance and inhibited macrophage infiltration in white adipose tissue through suppression of MCP-1 mRNA expression after 4 weeks feeding. Further, fucoxanthinol, which is one of fucoxanthin metabolites, also regulated cross talk of adipocytes and macrophages via palmitic acid and TNF-α. These results suggest that anti-inflammatory effects are molecular mechanism for anti-obesity and anti-diabetic effects of fucoxanthin.

虾青素对葡聚糖硫酸钠诱导的小鼠结肠炎和炎症相关结肠癌的发生具有抑制作用。在喂食虾青素的小鼠结肠中，通过抑制NF-κB活化来抑制炎性细胞因子如TNF-α和IL-1β的mRNA表达水平。饲喂20周后，含200 ppm虾青素的饲料可抑制结肠粘膜溃疡、异型增生隐窝和结肠腺癌。此外，从海洋生物中分离的虾青素、果胶烯醇酮、别黄质和硅藻黄质减弱了LPS激活的巨噬细胞中炎性细胞因子和考克斯-2和iNOS的过度mRNA表达。另一方面，0.2%岩藻黄质显著抑制炎症细胞因子如TNF-α和IL-6的mRNA表达，从而诱导胰岛素抵抗，并通过抑制MCP-1 mRNA表达来抑制白色脂肪组织中的巨噬细胞浸润。此外，岩藻黄素代谢产物之一岩藻黄素醇也通过棕榈酸和TNF-α调节脂肪细胞和巨噬细胞的串扰。这些结果表明，抗炎作用是岩藻黄质抗肥胖和抗糖尿病作用的分子机制。

项目成果

Anti-inflammatory effects of marine carotenoids on DSS-induced colitis in mice

海洋类胡萝卜素对 DSS 诱导的小鼠结肠炎的抗炎作用

• 发表时间: 2010
• 作者: M.Hosokawa;Y.Yasui;K.Miyashita;T.Tanaka
• 通讯作者: T.Tanaka

Inhibitory effects of fucoxanthin on colitis-related colon carcinogenesis in mice.

岩藻黄质对小鼠结肠炎相关结肠癌的抑制作用。

• 发表时间: 2010
• 作者: Kamiyama;T.;Suzuki;T.;Y.Yasui
• 通讯作者: Y.Yasui

カロテノイドの科学と最新応用技術(第7章 予防医学とカロテノイド)

类胡萝卜素科学与最新应用技术（第七章预防医学与类胡萝卜素）

• 发表时间: 2009
• 作者: 安井由美子;田中卓二
• 通讯作者: 田中卓二

Chapter 32. Antiobesity effect of fucoxanthin from edible seaweeds and its multibiological functions., in "Functional Food and Health"

《功能性食品与健康》第32章食用海藻中岩藻黄质的抗肥胖作用及其多生物功能。

• 发表时间: 2008
• 作者: H. Maeda;M. Hosokawa;T. Sashima;K. Miyashita
• 通讯作者: K. Miyashita

脂肪酸により誘導される炎症性マクロファージに対するフコキサンチノールの抑制作用

岩藻黄醇对脂肪酸诱导的炎症巨噬细胞的抑制作用

• 发表时间: 2009
• 作者: 江美信吾;細川雅史;宮下和夫
• 通讯作者: 宮下和夫