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Erythrocyte filterability inspontaneously hypertensive rats and its relation to hypertensive course and hemodynamics

自发性高血压大鼠红细胞滤过性及其与高血压病程和血流动力学的关系

基本信息

批准号：
18500328
负责人：
MARUYAMA Toru
金额：
$ 1.31万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18500328/
关键词：
Erythrocyte Filterability Hypertension Rat Rheology 微小循環

项目摘要

Hypertension is a common disease which induces arterial angiopathy impairing various functions of vital organs such as heart, brain and kidneys. Although elevation of blood pressure is considered to be due to an increase of peripheral vascular resistance, the role of vasoconstriction on rheological blood properties, especially on erythrocyte deformability is unknown. Spontaneously hypertensive rat (SHR) is a popular and excellent model of human hypertension. In the present study, we investigated the role of erythrocyte deformability in SHR in relation to the development and maintenance of high blood pressure, using the nickel mesh filtration technique. In this quantitative, sensitive and reproducible technique, erythrocyte deformability is considered as erythrocyte filterability. Age-matched Wistar rats were used as a control. We found that erythrocyte filterability was gradually impaired according to the aging of SHR, i.e., erythrocyte filterability was 56.3 ± 0.7% in 7 week-old, 50.3 ± 0.3% in 13 week-old and 49.3 ± 0.3% in 18 week-old. On the other hand, erythrocyte filterability in control rats was 61.9 ± 2.0% in 7 week-old and 56.1 ± 2.1% in 13 week-old. Therefore, impairment of erythrocyte filterability relative to control rat was evident more in young SHR. This indicates vasoconstriction under the development of hypertension in young SHR induces mechanical stress on circulating intact erythrocytes which causes inhibition of filterability and deformability of erythrocytes and this may further impairs microcirculation and lead to the maintenance of hypertension.

高血压是一种常见疾病，可导致动脉血管病变，损害心、脑、肾等重要器官的各种功能。虽然血压升高被认为是由于外周血管阻力的增加，但血管收缩对血液流变性，特别是对红细胞变形能力的影响尚不清楚。自发性高血压大鼠(SHR)是一种流行的优秀的人类高血压模型。在这项研究中，我们使用镍网过滤技术，研究了自发性高血压患者红细胞变形性在高血压的发生和维持中的作用。在这种定量、灵敏和可重复性的技术中，红细胞变形性被认为是红细胞的滤过性。以年龄匹配的Wistar大鼠为对照。结果发现，随着SHR年龄的增长，红细胞的滤过性逐渐减弱，7周龄为56.3±0.7%，13周龄为50.3±0.3%，18周龄为49.3±0.3%。对照组大鼠红细胞滤过率7周龄为61.9±2.0%，13周龄为56.1±2.1%。因此，与对照组相比，幼年自发性高血压大鼠的红细胞滤过性受损更为明显。提示青年SHR在高血压发展过程中的血管收缩作用，对循环完整的红细胞产生机械应力，使红细胞的滤过性和变形性受到抑制，从而进一步损害微循环，导致高血压的维持。