The NO conjugated-albumin nanoparticles for the application to multidisciplinary cancer treatment

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The enhanced permeability and retention (EPR) effect is a unique phenomenon of solid tumors related to their anatomical and pathophysiological differences from normal tissues, served as a basis for development of macromolecular anticancer therapy. Although many factors that affect vascular permeability in tumors have been identified, some parts of tumors do not exhibit the EPR effect and show less accumulation of macromolecules than other parts. We previously developed S-nitrosated HSA-Dimer (SNO-HSA-Dimer) as an enhancer of the EPR effect by applying nitric oxide (NO)-releasing agents in tumors selectively. In this study, we performed the effect of SNO-HSA-Dimer on the anti-tumor effect of two macromolecular anti-tumor drugs in C26 tumor-bearing mice. Intriguingly, SNO-HSA-Dimer inhibited the side effects of Doxil; through augmenting the EPR effect.