Strategy for the personalized medicine of molecular target drug based on the polymorphism information of plasma protein

点击翻译按钮获取中文摘要

We determined the crystal structures of complexes of the A variant AGP with some drugs. Comparison of our results with the structure of F1*S variant provides important new insights into the mechanism of the drug-binding selectivity of AGP variants. In addition, we explored the mechanism involved in hepatic cellular uptake of AGP. The findings indicate that hemoglobin beta-subunit contributes to the hepatocellular uptake of AGP, and AGP is incorporated via caveolae/lipid rafts pathway.