Ultrasound imaging for tissue characterization to assess cardiac re-synchronization therapy in chronic heart failure

用于组织表征的超声成像以评估慢性心力衰竭的心脏再同步治疗

• 批准号: 18500389
• 负责人: KAWABATA Masaaki
• 金额: $ 2.53万
• 依托单位: Hyogo College of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18500389/
• 关键词: Heart Failure; Chronic Heart Failure; Cardiac Re-synchronization Therapy; Ultrasound; Tissue Characterization; 循環器心不全; 循環器・心不全; 超音波

We obtained ultrasonic radio-frequency (RF) signals in the left ventricular posterior wall, in addition to tissue Doppler strain imaging in patients with chronic heart failure based on DCM. The signals were analyzed to determine correlation dimension (CD) which reflects chaotic behavior of RF signals on the basis of chaos theory. We observed the value of CD in patients with DCM is lower than that of normal subjects. We attempted to explore changes in ultrasonic properties of the myocardium following antihypertensive medication (such as calcium channel blocker or angiotensin receptor blocker) in hypertensive patients. The administration of those drugs caused non-uniform changes in the chaotic nature of the ultrasound signals. Though the mean value of CD did not change, distribution of CD values decreased after medication. In patients with CD of lower 2.8 before medication, there was an increase in CD following administration. This change was associated with an increase in E', an index of LV diastolic filling. Possible reduction of myocardial fibrosis is associated with an increase in the value of CD. We also attempt to estimate the chronic effects of cardiac resynchronization therapy in the future research by using this method as well as tissue Doppler strain imaging in patients with chronic heart failure.

我们获得了超声射频（RF）信号在左心室后壁，除了组织多普勒应变成像的慢性心力衰竭患者的DCM的基础上。根据混沌理论，对信号进行分析，确定反映射频信号混沌行为的关联维数。我们观察到扩张型心肌病患者的CD值低于正常人。我们试图探讨高血压患者服用抗高血压药物（如钙通道阻滞剂或血管紧张素受体阻滞剂）后心肌超声特性的变化。这些药物的施用导致超声信号的混沌性质的不均匀变化。用药后CD均值无变化，但CD值分布降低。在用药前CD低于2.8的患者中，用药后CD增加。这种变化与E '（左室舒张充盈指数）增加有关。心肌纤维化的可能减少与CD值的增加相关。我们也尝试在未来的研究中，通过使用这种方法以及组织多普勒应变成像在慢性心力衰竭患者中估计心脏起搏治疗的慢性效应。

项目成果

Characterization of left ventricuiar filling abnormalities and its relation to elevated plasma brain natriuretic peptide level in acute to chronic diastolic heart failure

急性至慢性舒张性心力衰竭左心室充盈异常的特征及其与血浆脑钠肽水平升高的关系

• 发表时间: 2007
• 期刊: Circ J 71・9
• 作者: Nakao S;Lee M;et. al.
• 通讯作者: et. al.

Left ventricular geometrical characterization in patients with diastolic heart failure

舒张性心力衰竭患者左心室几何特征

• 发表时间: 2007
• 期刊: J Echocardiogr 5・1
• 作者: Ezumi A;Lee M;et. al.
• 通讯作者: et. al.

Left ventricular geometrical characterization in patients with diastolic heart failure.

舒张性心力衰竭患者的左心室几何特征。

• 发表时间: 2007
• 期刊: J Echocardiogr 5(1)
• 作者: Ezumi A;Nakao S;Goda A;Otsuka M;Matsumoto M;Yoshida C;Eguchi A;Shimoshikiryo M;Naito Y;Lee M;Tsujino T;Masuyama T.
• 通讯作者: Masuyama T.

Loop diuretic precipitated beriberi in a patient after pancreaticoduodenectomy: A case report

• DOI: 10.1097/maj.0b013e318068b5d5
• 发表时间: 2007-11-01
• 期刊: AMERICAN JOURNAL OF THE MEDICAL SCIENCES
• 影响因子: 3.1
• 作者: Tsujino, Takeshi;Nakao, Shinji;Masuyama, Tohru
• 通讯作者: Masuyama, Tohru

Left ventricular diastolic dysfunction in diabetic patients : pathophysiology and therapeutic implications.

糖尿病患者的左心室舒张功能障碍：病理生理学和治疗意义。

• 发表时间: 2006
• 期刊: Am J Cardiovasc Drugs 6. 4
• 作者: Tsujino T;Masuyama T;et al.
• 通讯作者: et al.