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Effect of bisphenol-A given neonatally on the genesis of rat oviduct

新生儿给予双酚A对大鼠输卵管发育的影响

基本信息

批准号：
18510057
负责人：
OHTA Yasuhiko
金额：
$ 2.64万
依托单位：
Tottori University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18510057/
关键词：
rat oviduct BPA endocrine disrupter neonatal 内分泌かく乱

项目摘要

Although bisphenol-A (BPA) used in the manufacture of polystyrene and epoxy resins is thought to be a potent endocrine disrupter in rodents, the detail effect on the reproductive function is still obscure. We have already reported that female rats treated with BPA neonatally showed regular estrous cycles at 60 days, and contained ovaries with follicles and corpora lutea. However, they had a few fetal swellings and abnormal swellings in the uteri on Days 10 and 18 of pregnancy. In the present report, uteri and oviducts were investigated in female rats of the T strain given 7 daily injections of 1 mg BPA from the day of birth. The BPA-treated rats showing regular estrous cycles around Day 60. In both the BPA-treated and control rats, the uteri formed deciduomata in response to uterine trauma given the 4 th day of a 7-day treatment with progesterone and estradiol in aduthood, but the resposne was smaller in the former than the latter. The number of ova ovulated in the oviduct at the first … More estrus after Day 60 was fewer in the BPA-treated rats than in the controls. The BPA-treated rats showed occlusion and disappearance of the INF, and inflammation in the epithlium and stromal tissue on Day 60. The rats with oviduct malformation often contained ova within the ovarian capsule, but not in the ampulla. The abnormality was not evident until Day 30 and occurred Day 40 onward. Female rats likewise treated with 0.01mg estradiol-17b showed normal estrus cycles and similar damages in the oviduct around Day 60. These findings indicate that the reduction of fetuses in the BPA-treated pregnant rats may be accounted, at least in part, for by the failure in transport of the ovum due to the malformation of oviducts, rather than to uterine response, eliciting estrogenic action of BPA. It is known that the oviduct malformation containing inflammation and adhesion in the INF is an important factor for female infertility in human. The present study may be one of useful models for evaluation of the effect of endocrine disruptors on the female reproductive disorder Less

虽然双酚A（BPA）用于聚苯乙烯和环氧树脂的生产被认为是一种有效的内分泌干扰物在啮齿动物，对生殖功能的详细影响仍然是模糊的。我们已经报道了用BPA处理的雌性大鼠在60天内表现出规则的发情周期，并含有卵泡和黄体的卵巢。然而，在妊娠第10天和第18天，它们有一些胎儿乳房和子宫内异常乳房。在本报告中，研究了从出生之日起每天注射1 mg BPA 7次的T品系雌性大鼠的子宫和输卵管。BPA处理的大鼠在第60天左右显示出规律的发情周期。BPA处理组和对照组大鼠在成年期给予孕酮和雌二醇治疗7天后的第4天，子宫对子宫损伤均形成蜕膜瘤，但前者的反应小于后者。第一次排卵时输卵管内的卵子数 ...更多信息 BPA处理组大鼠第60天后的发情期少于对照组。BPA处理的大鼠在第60天显示INF闭塞和消失，以及上皮和基质组织中的炎症。输卵管畸形大鼠卵巢囊内常含卵，壶腹部无卵。该异常在第30天之前不明显，并在第40天之后发生。同样，用0.01 mg雌二醇-17 b处理的雌性大鼠在第60天左右表现出正常的发情周期和相似的输卵管损伤。这些结果表明，BPA处理的孕鼠中胎儿的减少可能至少部分是由于输卵管畸形导致的卵子运输失败，而不是子宫反应，引发BPA的雌激素作用。输卵管畸形是导致女性不孕的重要因素之一。本研究为评价内分泌干扰物对女性生殖功能障碍的影响提供了一个有用的模型。