Detection of clinically insignificant prostate cancer by allelic imbalance analysis

通过等位基因不平衡分析检测临床上不显着的前列腺癌

• 批准号: 18590350
• 负责人: TAKAHASHI Hiroyuki
• 金额: $ 2.12万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590350/
• 关键词: cancer; pathology; cell. tissue; 前立腺癌; 微小癌; ラテント癌; LOH

The criterion tumor volume (TV) for clinically insignificant prostate cancer has been reported, but it differs from study to study : some have reported TV < 200 mm^3 ; others, <500 mm^3. The aim of the present study was to distinguish clinically insignificant cancers from significant ones using molecular biological methods. A total of 184 microscopic cancers (MC) defined as limited within a 3 mm circle and 82 main tumor (MT) nodules were selected. Thirteen microsatellite loci at 6q22, 8p23.2-23, 13q14 and 13q33 were evaluated for loss of heterozygosity (LOH). MT were subgrouped as TV <500 mm^3 or > 500 mm^3 ; TV < 200 mm^3 or > 200 mm^3 ; and TV < 200 mm^3 or 200 mm^3 〓 TV < 500 mm^3 or〓500 mm^3 ; and frequencies of LOH were compared between these three groups. Frequencies of LOH at 6q16-21, 6q22, 8p23.1, 8p23.2, 13q14 were significantly lower in MC (1.0%, 2.7%, 1.9%, 1.1% and 5.4%) than in MT (30.9%, 40.4%, 12%, 8.7% and 20.6%). No significant differences in LOH frequencies were found at any of these TV settings. When insignificant tumor is defined as TV < 200 mm^3 or < 500 mm^3, it should include tumors with malignant potential equivalent to larger tumors. It is suggested that in order to identify insignificant tumor within a strict safety range, TV should be set lower.

据报道，用于临床上无关的前列腺癌的标准肿瘤体积（TV），但研究与研究之间有所不同：有些人报道了电视<200 mm^3;其他，<500 mm^3。本研究的目的是使用分子生物学方法将临床上微不足道的癌症与重要癌症区分开。总共选择了184个显微镜癌（MC）在3毫米圆圈内定义为有限，并选择了82个主肿瘤（MT）结节。评估了杂合性损失（LOH）的第6q22、8p23.2-23、13q14和13q33的13个微卫星基因座。 MT被亚组为电视<500 mm^3或> 500 mm^3;电视<200 mm^3或200 mm^3〓电视<500 mm^3或〓500mm^3;在这三组之间比较了LOH的频率和频率。 LOH在2016-21、6q22、8p23.1、8p23.2、13Q14的LOH的频率在MC中显着降低（1.0％，2.7％，1.9％，1.9％，1.1％和5.4％）（30.9％，40.4％，12％，8.7％，8.7％和20.6％）。在这些电视设置中的任何一个中，LOH频率均未发现显着差异。当将肿瘤微不足道的肿瘤定义为电视<200 mm^3或<500 mm^3时，应包括具有与较大肿瘤的恶性潜在的肿瘤。建议为了在严格的安全范围内识别微不足道的肿瘤，应将电视设置较低。

项目成果

Prediction of clinically insignificant prostate cancer by detection of allelicimbalance at 6q,8p and 13q

通过检测 6q、8p 和 13q 等位基因不平衡来预测临床上不显着的前列腺癌

• 期刊: Pathol Int (印刷中)
• 作者: Nakano M;Takahashi H;et. al.
• 通讯作者: et. al.

Prediction of clinically insignificant prostate cancer by detection of allelic imbalance at 6q, 8p and 13q

通过检测 6q、8p 和 13q 等位基因不平衡来预测临床上不显着的前列腺癌

• 发表时间: 2008
• 期刊: Pathol Int 58
• 作者: Nakano;M;Takahashi;H;et. al.
• 通讯作者: et. al.

Therapeutic applications of allelic imbalance and immunohistochemistry in prostate cancers

等位基因失衡和免疫组织化学在前列腺癌中的治疗应用

• 发表时间: 2007
• 作者: Nakano M;Takahashi H;et. al.;Takahashi H
• 通讯作者: Takahashi H

Prediction of clinically insignificant prostate cancer by detection of allelic imbalance at 6q,8p and 13q

通过检测 6q、8p 和 13q 等位基因失衡预测临床上不显着的前列腺癌

• 发表时间: 2008
• 期刊: Pathol Int
• 影响因子: 2.2
• 作者: Nakano M;Takahashi H;et. al.
• 通讯作者: et. al.

13q,6q,8p領域LOH解析による前立腺微小癌と主腫瘍の差

13q、6q、8p区域LOH分析前列腺微小癌与主肿瘤的差异

• 发表时间: 2007
• 作者: 中野 雅貴;鷹橋 浩幸;ら
• 通讯作者: ら