The role of TEL in embryonic stem cell differentiation, and identification of a new interacting protein.

建立了表达野生型TEL和TEL- trkc融合基因的小鼠胚胎干（ES）细胞，该基因在白血病和婴儿纤维肉瘤中都是致癌因子。将胚胎干细胞分化为造血细胞，并对其进行详细分析，以阐明其在肿瘤发生中所必需的功能。表达野生型TEL的ES细胞倾向于停留在未成熟的造血细胞中，而表达TEL- trkc的ES细胞不能分化为内皮细胞和血细胞的常见前体成血管细胞，其产生造血干细胞的能力严重受损。中胚层来源的未成熟细胞增加，而不是血细胞，这可能是TEL-TRKC窝藏纤维肉瘤的癌症干细胞。目前正在研究TEL相互作用蛋白与肿瘤发生的关系。

Murine embryonic stem (ES) cells expressing wild type TEL and TEL-TRKC fusion gene, identified as an oncogenic factor in both leukemia and infantile fibrosarcoma, were established. The ES cells were differentiated into hematopoietic cells and analyzed in detail to clarify its function necessary for tumorigenesis. ES cells expressing wild type TEL had the tendency to remain in immature hematopoietic cells, whereas TEL-TRKC expressing ES cells could not differentiate into hemangioblast, a common precursor of endothelial and blood cells, and their capacity to produce hematopoietic stem cells were severely impaired. Mesoderm derived, immature cells increased instead of blood cells, which might be the cancer stem cells for TEL-TRKC harboring fibrosarcoma. Interacting protein to TEL is now being investigated for its association with tumorigenesis.