Development of auto-IAP-antibody screening array for diagnosing cancer patients

开发用于诊断癌症患者的自身 IAP 抗体筛查阵列

• 批准号: 18390174
• 负责人: WATANABE Naoki
• 金额: $ 10.67万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390174/
• 关键词: 臨床検査医学; 抗IAP抗体; 癌診断; 抗体検出アレイ; Immuno-PCR法

分子生物学の進歩に伴い, 癌で発現が亢進あるいは低下し, 浸潤・転移能の増強や治療抵抗性の発現と密接に関与する分子群が, 報告されるようになった。今回我々は, 抗Survivin, LivinおよびXIAP自己抗体に注目し, 各種消化器癌, 肺癌や乳癌患者の血清診断を試みた。癌患者29例中14例(48%)で, いずれかの自己抗体が検出された。なかでも, 抗Survivin自己抗体の陽性率が最も高く, 45%(13/29)であった。

The progress of molecular biology is accompanied by the development of cancer, the development of cancer and the improvement of cancer resistance, the development of infiltration and the improvement of resistance to treatment, and the close connection between the development of cancer and the development of molecular groups. Report されるようになった. This time I will focus on the anti-Survivin, Livin and XIAP autoantibodies, and test serodiagnosis for patients with various digestive cancers, lung cancer, and breast cancer. Among the 29 cancer patients, 14 (48%) had autoantibodies. The positive rate of anti-Survivin autoantibodies is the highest, 45% (13/29).

项目成果

15-Deoxy-Delta (12, 14)-prostaglandin J(2) inhibits G(2)-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivn expression

15-脱氧-Delta (12, 14)-前列腺素 J(2) 通过下调细胞周期蛋白 B1 和存活蛋白表达抑制人乳腺癌细胞的 G(2)-M 期进展

• 发表时间: 2007
• 期刊: Breast Cancer Res Treat 102
• 作者: Kamagata C;Tsuji N;Moriai M;Kobayashi D;Watanabe N.
• 通讯作者: Watanabe N.

Interaction between survivin and aurora-B kinase plays an important role in survivin-mediated up-regulation of human telomerase reverse transcriptase expression

• DOI: 10.3892/ijo_00000232
• 发表时间: 2009-04-01
• 期刊: INTERNATIONAL JOURNAL OF ONCOLOGY
• 影响因子: 5.2
• 作者: Furuya, Momoko;Tsuji, Naoki;Watanabe, Naoki
• 通讯作者: Watanabe, Naoki

Carcinoembryonic antigen - Targeted selective gene therapy for gastric cancer through FZ33 fiber-modified adenovirus vectors

• DOI: 10.1158/1078-0432.ccr-06-0024
• 发表时间: 2006-06-15
• 期刊: CLINICAL CANCER RESEARCH
• 影响因子: 11.5
• 作者: Tanaka, Toshihiro;Huang, Jianhua;Hamada, Hirofumi
• 通讯作者: Hamada, Hirofumi

Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor-induced apoptosis in cancer

• DOI: 10.1074/jbc.m610350200
• 发表时间: 2007-07-06
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Kaneko, Reiko;Tsuji, Naoki;Watanabe, Naoki
• 通讯作者: Watanabe, Naoki

Inhibition of estrogen receptor β-mediated human telomerase reverse transcriptase gene transcription via the suppression of mitogen-activated protein kinase signaling plays an important role in 15-deoxy-Δ ^<12, 14>-prostaglandin J2-induced apoptosis in ca

通过抑制丝裂原激活蛋白激酶信号传导抑制雌激素受体 β 介导的人端粒酶逆转录酶基因转录，在 15-脱氧-Δ^<12, 14>-前列腺素 J2 诱导的细胞凋亡中发挥重要作用

• 发表时间: 2007
• 期刊: Exp Cell Res 313
• 作者: Kondo K;Tsuji N;Asanuma K;Kobayashi D;Watanabe N
• 通讯作者: Watanabe N