Development of auto-IAP-antibody screening array for diagnosing cancer patients
Development of auto-IAP-antibody screening array for diagnosing cancer patients
批准号:
18390174
负责人:
WATANABE Naoki
金额:
$10.67万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2006
资助国家:
日本
项目状态:
已结题
起止时间:
2006 至 2008
中文摘要
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英文摘要
分子生物学の進歩に伴い, 癌で発現が亢進あるいは低下し, 浸潤・転移能の増強や治療抵抗性の発現と密接に関与する分子群が, 報告されるようになった。今回我々は, 抗Survivin, LivinおよびXIAP自己抗体に注目し, 各種消化器癌, 肺癌や乳癌患者の血清診断を試みた。癌患者29例中14例(48%)で, いずれかの自己抗体が検出された。なかでも, 抗Survivin自己抗体の陽性率が最も高く, 45%(13/29)であった。
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15-Deoxy-Delta (12, 14)-prostaglandin J(2) inhibits G(2)-M phase progression in human breast cancer cells via the down-regulation of cyclin B1 and survivn expression
15-脱氧-Delta (12, 14)-前列腺素 J(2) 通过下调细胞周期蛋白 B1 和存活蛋白表达抑制人乳腺癌细胞的 G(2)-M 期进展
DOI:
--
发表时间:
2007
期刊:
Breast Cancer Res Treat 102
影响因子:
--
作者:
[Kamagata C, Tsuji N, Moriai M, Kobayashi D, Watanabe N.]
通讯作者:
Watanabe N.
DOI:
10.3892/ijo_00000232
发表时间:
2009-04-01
期刊:
INTERNATIONAL JOURNAL OF ONCOLOGY
影响因子:
5.2
作者:
[Furuya, Momoko, Tsuji, Naoki, Watanabe, Naoki]
通讯作者:
Watanabe, Naoki
DOI:
10.1158/1078-0432.ccr-06-0024
发表时间:
2006-06-15
期刊:
CLINICAL CANCER RESEARCH
影响因子:
11.5
作者:
[Tanaka, Toshihiro, Huang, Jianhua, Hamada, Hirofumi]
通讯作者:
Hamada, Hirofumi
DOI:
10.1074/jbc.m610350200
发表时间:
2007-07-06
期刊:
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子:
4.8
作者:
[Kaneko, Reiko, Tsuji, Naoki, Watanabe, Naoki]
通讯作者:
Watanabe, Naoki
Inhibition of estrogen receptor β-mediated human telomerase reverse transcriptase gene transcription via the suppression of mitogen-activated protein kinase signaling plays an important role in 15-deoxy-Δ ^<12, 14>-prostaglandin J2-induced apoptosis in ca
通过抑制丝裂原激活蛋白激酶信号传导抑制雌激素受体 β 介导的人端粒酶逆转录酶基因转录,在 15-脱氧-Δ^<12, 14>-前列腺素 J2 诱导的细胞凋亡中发挥重要作用
DOI:
--
发表时间:
2007
期刊:
Exp Cell Res 313
影响因子:
--
作者:
[Kondo K, Tsuji N, Asanuma K, Kobayashi D, Watanabe N]
通讯作者:
Watanabe N
共 18 条
Examining the risk of developing Alzheimer's disease induced by decreased expression of ILEI
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nalyses of Disciplinary Mechanism towards Executives: Lesson from
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Payoff Allocation Problem in Patent Pools: Coalition Formation, Investment in Development, and Efficiency
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Deuterium fractionation of water molecule via grain surface reactions at very low temperatures
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Ice surface processes: tunneling reactions and isotope fractionation
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依托单位:
Development of auto-IAP-antibody screening array for diagnosing cancer patients.
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批准号:21390183
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.31万
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依托单位:
Elucidation of acute actin polymerization signaling using single molecule imaging of filament end factors
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依托单位:
Role of cosmic-grain surface reactions in the deuterium fractionationof interstellar molecules
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A Theoretical and Empirical Research on Dynamic Industry Structure : Research and Development, License, Endogenous Coalition Formation
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依托单位:
Actin-polymerization-driven molecular dynamics of Formin homology proteins in live cells
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依托单位:
Single-molecule imaging analysis of cell structural reorganization processes downstream of G protein signaling
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依托单位:
Surface reactions of atoms and the mechanism of deuterium fractionation on inter Stellar dusts at the very low temperature
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依托单位:
Development of new therapy for pancreas cancer using PPAR γ-ligand targeting hTERT.
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Identification of intracellular signaling cascade of Rho and mDia1 based on high sensitivity live-cell imaging
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依托单位:
Establishment of gene therapy for panceratic cancer, targeting genes for the components of telomerase and telomeric-repeat binding proteins.
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The social and cultural Research on German Enlightenment
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Helicobacter pylori infection augments telomerase activity in gastric cancer and noncancerous tissues
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Specific interaction of pancreatic elastase and leukocytes to produce oxygen radicals and its implication in pancreatitis
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依托单位: