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Comparative Analyses of the Main Olfactory Bulb : Rodent and Insectivore

主要嗅球的比较分析：啮齿动物和食虫动物

基本信息

批准号：
18500265
负责人：
KOSAKA Katsuko
金额：
$ 2.52万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

Glomeruli of the main olfactory bulb (MOB) are now considered to serve as functional units in the olfactory information processing. We confirmed the compartmental organization of the glomerulus and the presence of both type 1 and 2 periglomerular cells in the mice. Similar to rat periglomerular cells, the tyrosine hydroxylase (TH) -positive cells were type 1 and GAD/GABA-positive. On the other hand, both the calbindin D28k (CB) -positive and calretinin (CR) -positive cells were type 2 periglomerular cells, but in contrast to those in rats, which are GAD/GABA-negative, all of the calbindin D28k-positive periglomerular cells and 50% of the calretinin-positive periglomerular cells were GAD/GABA-positive. The GAD/GABA-positive cells thus included both type 1 and type 2 periglomerular cells. Juxtaglomerular NOS-positive cells have been proposed as a subgroup of type 1 periglomerular cells that are separate from the CR-positive and CB-positive cells in rats. However, in the mice, about 70% of the NOS-positive cells were calretinin-positive, and 50% of the CR-positive cells were NOS-positive. We herein reveal the significant species differences in the chemical properties of periglomerular cells and suggest that the cellular organization of the mouse main olfactory bulb cannot be extrapolated from that of rats.Furthermore, we reported the precise distribution and characteristic features of NOS-positive and PV-positive neurons in the mouse MOB.

主嗅球（MOB）的肾小球被认为是嗅觉信息处理的功能单位。我们证实了小鼠肾小球的房室组织和1型和2型肾小球周围细胞的存在。与大鼠肾小球周围细胞相似，酪氨酸羟化酶（TH）阳性细胞为1型和GAD/GABA阳性。另一方面，钙结合蛋白D28 k（CB）阳性细胞和钙网膜蛋白（CR）阳性细胞均为2型肾小球周围细胞，但与GAD/GABA阴性的大鼠相比，所有钙结合蛋白D28 k阳性的肾小球周围细胞和50%的钙网膜蛋白阳性的肾小球周围细胞均为GAD/GABA阳性。因此，GAD/GABA阳性细胞包括1型和2型肾小球周围细胞。肾小球旁NOS阳性细胞被认为是1型肾小球周围细胞的一个亚群，与大鼠的CR阳性细胞和CB阳性细胞不同。然而，在小鼠中，约70%的NOS阳性细胞为钙视网膜蛋白阳性，50%的CR阳性细胞为NOS阳性。本文揭示了肾小球周围细胞化学性质的显著种属差异，并表明小鼠主嗅球的细胞结构不能从大鼠的外推。此外，我们报道了小鼠MOB中NOS阳性和PV阳性神经元的精确分布和特征。