Structural organization of the main olfactory bulb: further analysis of juxtaglomerular neurons

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Juxtaglomerular (JG) neurons in the mouse main olfactory bulb (MOB) consist of various types of neurons. In the present study we examined (1) the structural features of secretagogin(SCGN)-positive neurons, and (2) The expressions of two transcription factors, Sp8 and Tbx21, in the JG neuronal subpopulations.SCGN-positive neurons were localized throughout layers, and heterogeneous, including JG neurons, granule cells, et al. Morphologically some of JG SCGN-positive neurons were classical periglomerular (PG) cells, whereas others were apparently different from those PG cells. Some extended one slender process into a glomerulus which passed the glomerulus and further penetrated into another nearby glomeruli. We named this type of JG neurons, transglomerular cells. Both Sp8 and Tbx21 immunoreactivities were so diverse in their staining intensities. Sp8 and Tbx21 immunoreactivities further characterized JG neurons and, especially confirmed the heterogeneity of NOS positive JG neurons.