LPS (lipopolysaccharide, endotoxin) susceptibility, an important factor in the innate immune response to Gram-negative bacterial infections. Benefits and hazards of LPS hypersensitivity

LPS（脂多糖，内毒素）敏感性，是对革兰氏阴性细菌感染的先天免疫反应的重要因素。

• 批准号: 5356930
• 负责人: Professorin Dr. Marina Alexandra Freudenberg
• 金额: --
• 依托单位: Klinik für Pneumologie
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2002
• 资助国家: 德国
• 起止时间: 2001-12-31 至 2007-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5356930?language=en
• 关键词: LPS; lipopolysaccharide; endotoxin; susceptibility; important

LPS (lipopolysaccharide, endotoxin) is a major component of the outer cell wall of Gram-negative bacteria. LPS plays an important role in the early recognition and in the defense against invading bacteria by the innate immune system. The activation of the innate immune system however, is not without complications for the infected organism. LPS is a potent inducer of many pathophysiological activities seen during infection, including the development of endotoxin shock, frequently with lethal outcome. With the proposed research project it is intended to make a useful contribution to the clarifying of genetic factors determining innate LPS susceptibility and to the understanding of the factors underlying the development of LPS hypersensitivity and its role in the course of infection. The objectives of the study are the following: A. To obtain definite evidence that TLR4 (Toll-like receptor 4) is the central recognition and signaling protein in the activation of cells by LPS. B. To study the involvement of IFN (Interferon)-a/b in the induction of IFN-g and thus in the induction of LPS hypersensitivity in infected host. The pathogen-induced IFN-g represents the key mediator of LPS hypersensitivity that develops during infection. C. To investigate the consequences of an existing LPS hypersensitivity on 1) the resistance to infection and 2) the risk of development of endotoxin shock. Both properties result from an activation of the innate immune system by LPS.

内毒素是革兰氏阴性菌细胞外壁的主要成分。内毒素在先天免疫系统对入侵细菌的早期识别和防御中起着重要作用。然而，先天免疫系统的激活对受感染的有机体来说并不是没有并发症。内毒素是感染过程中许多病理生理活动的有效诱因，包括内毒素休克的发展，通常会导致致命的后果。本研究旨在为阐明决定内毒素先天易感性的遗传因素、了解内毒素超敏反应发生的因素及其在感染过程中的作用做出有益的贡献。本研究的目的如下：1.确定TLR4(Toll-like Receptor 4，Toll样受体4)是脂多糖激活细胞的中枢识别和信号蛋白。B.研究干扰素(干扰素)-a/b在干扰素-g的诱导中的作用，从而在感染宿主中诱导内毒素超敏反应。病原体诱导的干扰素-g是在感染过程中形成的内毒素超敏反应的关键介质。C.调查现有的内毒素超敏反应在1)对感染的抵抗力和2)发展内毒素休克的风险方面的后果。这两种特性都是由于内毒素激活了先天免疫系统。