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Regulatory mechanisms of the strength of endotoxin signaling

Regulatory mechanisms of the strength of endotoxin signaling
内毒素信号强度的调节机制
批准号:
21590502
负责人:
TANAMOTO Kenichi
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
To clarify the regulatory mechanisms of the strength of endotoxin signaling, relationship between its activity and the binding to the receptor protein was studied. The affinity of lipid A compounds(active molecule of endotoxin) to human and mouse LBP was in following order ; 406>506>516. The order was roughly paralleled with their activities in murine cells but not with those in human cells, indicating that the process following the binding to LBP plays an important role in the regulation of the strength of endotoxin signaling.
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