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An experimental studyonimage analysis and resuscitation of tissue dysoxia

组织缺氧图像分析与复苏的实验研究

基本信息

批准号：
18591981
负责人：
AOKI Katsunori
金额：
$ 2.55万
依托单位：
Hamamatsu University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591981/
关键词：
dysoxia shock tissue oxygen metabolism ileum Pd-porphrin arterioyenous shunt endotoxin 酸素代謝 P.d-porphrin

项目摘要

The purpose of this study was to evaluate and resuscitate tissue dysoxia in an experimental model of endotoxin shock. Twenty rabbits (Japan White Rabbits, BW 3kg) were assigned to endotoxin shock model induced by LPS (Escherichia coli-055: B5, 1 mg/kg). The value of ileum serosal oxygen partial pressure was measured by two methods: Clerk-type oxygen electrodes, and Pd-porphyrin phosphorescence (Oxygen Map System). The value of ileum serosal oxygen partial pressure decreased in endotoxin shock and showed lower than the value of venous oxygen partial pressure. This gap of oxygen partial pressure was likely due to heterogeneous distribution of oxygen in ileum serosal by image analysis of Oxygen Map System. We conclude that tissue dysoxia may form at an early stage in endotoxin shock and shunting of the microcirculation may be an important contributing factor to development of tissue dysoxia. The image analysis of tissue dysoxia will need to be developed about analysis of heterogeneous distribution of oxygen in tissue in order to evaluate the severity of the shunting effect, as well as to evaluate an effect of new drugs aimed at improving the microcirculation shuntig.

本研究的目的是评估和复苏组织缺氧的实验模型内毒素休克。日本白色家兔20只，体重3 kg，随机分为内毒素休克模型组（Escherichia coli-055：B5，1 mg/kg）。采用Clerk型氧电极法和Pd-卟啉磷光法（Oxygen Map System）测定回肠浆膜氧分压。内毒素休克时回肠血清氧分压降低，并低于静脉氧分压。通过氧图系统的图像分析，这种氧分压的差距可能是由于回肠浆膜内氧分布不均匀所致。我们的结论是，组织缺氧可能形成在早期阶段，内毒素休克和分流的微循环可能是一个重要的因素，发展组织缺氧。组织缺氧的图像分析将需要开发关于组织中氧的不均匀分布的分析，以评估分流效应的严重性，以及评估旨在改善微循环分流的新药的效果。

项目成果

期刊论文数量（0）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A report of two cases of suspected food-dependent exercise-induced anaphylaxis.

两例疑似食物依赖性运动诱发过敏反应的报告。

DOI：
发表时间：
2006
期刊：
Chubu J of Acute medicie 1
影响因子：
0
作者：
Dohi K;Satoh K;Shioda S;Aruga T;et al.;志馬伸朗ら;青木克憲;志馬伸朗;Nishina Masayoshi
通讯作者：
Nishina Masayoshi

体液変動(熱傷治療マニュアル、分担執筆)

液体波动（烧伤治疗手册，合著者）

DOI：
发表时间：
2007
期刊：
影响因子：
0
作者：
Kenii;Dohi;Tomoya;Nakamachi;Sachiko;Yofu;Yuko;Mihara;Kentaro;Morikawa;Hirokazu;Ohtaki;Kazue;Satoh;Seiji;Shioda;Tohru;Aruga;青木克憲;青木克憲
通讯作者：
青木克憲

A report of two cases of suspected food-dependent exercise-induced anaphylaxis

疑似食物依赖性运动诱发过敏反应两例报告