Development of closed-loop cardiac-cycle artificial respiration to increase cardiac output

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We developed a open-loop cardiac-cvcle artificial respiration. In addition, we further developed a closed-loop cardiac-cycle artificial respiration that increases cardiac output. Our system consisted of a personal computer that received information about respiratory condition from variable sensors around patients and that about cardiovascular condition from pressure and flow sensors located in patients. The personal computer then controlled ventilator to adjust airway pressure by DA output and to increased cardiac output while maintaining respiratory and cardiovascular conditions. In animal experiments in dog with normal heart, our system succeeded to increased cardiac output by 5-10%. Out system also worked well in dogs with failing heart. In addition, our system decreased the amount of inotropic agents needed to maintain hemodynamics since it was able to increase cardiac output. Accordingly, our system may be useful in respiratory and cardiovascular control of intensive care medicine.