Development of automated medical system to support management of circulation

开发支持流通管理的自动化医疗系统

• 批准号: 20390462
• 负责人: KAMIYA Atsunori
• 金额: $ 12.31万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390462/
• 关键词: 集中治療医学; 循環; 心不全; 左心房圧; 肺動脈圧; 右心房圧; 自動治療; 医工学

Management of circulation in intensive care medicine is important and high quality specialized medical treatment, that directly determines vital prognosis of patients. However, physicians have great physical stress in background of their insufficiency in recent days, that lead human errors in medical treatment that are widely recognized as social problems. The present study, as a challenge to resolve the problems by technology-driven automated medical system, developed multiple drug-delivery system that makes a diagnosis about cardiovascular dynamics and deliver four drugs simultaneously in treatment, with particularly changing open-chest limited to closed-chest applicable system. It actually restored cardiovascular dynamics of animals (i.e., dogs) with circulatory failure.

重症监护医学中的循环管理是重要的、高质量的专科医疗，直接决定着病人的生命预后。然而，近年来，医生在自身能力不足的情况下，面临着巨大的身体压力，导致医疗人为失误成为社会普遍关注的问题。本研究以技术驱动的自动化医疗系统解决问题为挑战，开发了多药物输送系统，该系统可以对心血管动力学进行诊断，并在治疗中同时输送四种药物，特别是将开胸限制为闭胸适用系统。它实际上恢复了动物的心血管动力学（即，犬）循环衰竭。

项目成果

In vivo direct monitoring of interstitial norepinephrine levels at the sinoatrial node

体内直接监测窦房结间质去甲肾上腺素水平

• 发表时间: 2010
• 期刊: Autonomic Neuroscience : Basic & Clinical 152
• 作者: Shuji Shimizu;Tsuyoshi Akiyama;Toru Kawada;Toshiaki Shishido;Masaki Mizuno;Atsunori Kamiya;Toji Yamazaki;Shunji Sano;Masaru Sugimachi.
• 通讯作者: Masaru Sugimachi.

Feedback control of multiple hemodynamic variables with multiple cardiovascular drugs.

使用多种心血管药物对多个血流动力学变量进行反馈控制。

• 发表时间: 2009
• 期刊: Conf Proc IEEE Eng Med Biol Soc. 1
• 作者: Sugimachi M;Uemura K;Kamiya A;et al.
• 通讯作者: et al.

Theoretical and experimental demonstration of minumizing 02 consumption under preserved hemodynamics in heart failure

在保持心力衰竭血流动力学的情况下最小化 O2 消耗的理论和实验论证

• 发表时间: 2008
• 作者: M. Sugimachi;K. Uemura;T. Shishido;A. Kamiya;S. Shimizu;K. Sunagawa
• 通讯作者: K. Sunagawa

Estimated venous return surface and cardiac output curve precisely predicts new hemodynamics after volume change

估计的静脉回流表面和心输出量曲线精确预测容量变化后的新血流动力学

• 发表时间: 2010
• 作者: Sugimachi M;Sunagawa K;Uemura K;Kamiya A;Shimizu S;Inagaki M;Shishido T
• 通讯作者: Shishido T

Closed-loop spontaneous baroreflex transfer function is inappropriate for system identification of neural arc but partly accurate for peripheral arc: predictability analysis

• DOI: 10.1113/jphysiol.2011.203455
• 发表时间: 2011-04-01
• 期刊: JOURNAL OF PHYSIOLOGY-LONDON
• 影响因子: 5.5
• 作者: Kamiya, Atsunori;Kawada, Toru;Sugimachi, Masaru
• 通讯作者: Sugimachi, Masaru