Neural mechanisms which induce blood pressure fluctuation during REM sleep

快速眼动睡眠期间引起血压波动的神经机制

• 批准号: 18603007
• 负责人: KAYAMA Yukihiko
• 金额: $ 2.62万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18603007/
• 关键词: Hypothalamus; Laterodorsal tegmental nucleus; Acetylcholine; Blood pressure; REM sleep; Autonomic nervous system; 外側視床下部; ラット; ムスカリン性受容体

During REM sleep, the homeostasis system does not show normal performance and large fluctuations of autonomic nervous systems appear. Little is known on the mechanisms how this fluctuation is generated and on the physiological significance of this fluctuation. In this study, the experiments were performed to elucidate the relationship of the hypothalamus and the brainstem for the regulation of blood pressure fluctuation during REM sleep, and we got the following results ;1. The hypothalamus of urethane anesthetized rats was electrically stimulated every 200-400 μm through a carbon fiber electrode which was moved by oil-pressure manipulator. Blood pressure increase was induced after the stimulation to the lateral hypothalamus (LHA) and its surroundings, while posterior to this effective area, blood pressure decrease was induced.2. Neuronal activity was recorded from unanesthetized head-restrained rats simultaneously with blood pressure. Some of the LHA neurons show close correlation with blood pressure increase during REM sleep.3.Last year, we found that the cholinergic neurons in the laterodorsal tegmental nucleus (LDT) showed the correlation with blood pressure increase during REM sleep. So, this year, we performed simultaneous recording from the LHA and LDT and found that when the blood pressure increase during REM sleep, the activity of the LDT neurons preceded that of the LHA neurons.These results suggest that for blood pressure fluctuation during REM sleep, the excitatory input from the LDT to the LHA have a crucial role.

在REM睡眠期间，内稳态系统不显示正常的性能，自主神经系统出现大的波动。关于这种波动是如何产生的机制以及这种波动的生理意义知之甚少。本研究旨在探讨下丘脑和脑干在REM睡眠期血压波动调节中的关系，主要结果如下：1.在乌拉坦麻醉大鼠下丘脑，用油压操纵器移动碳纤维电极，每隔200-400 μm电刺激一次。刺激下丘脑外侧（LHA）及其周围区域后，血压升高，而刺激该有效区域后，血压降低。2.神经元活动记录从未麻醉的头部约束大鼠同时血压。部分LHA神经元与REM睡眠期血压升高密切相关。3.近年来，我们发现被盖背外侧核（LDT）内的胆碱能神经元与REM睡眠期血压升高相关。因此，今年，我们进行了LHA和LDT的同步记录，发现当REM睡眠期间血压升高时，LDT神经元的活动先于LHA神经元的活动。这些结果表明，对于REM睡眠期间的血压波动，LDT到LHA的兴奋性输入起着至关重要的作用。

项目成果

Neuron groups in the activation system in the brainstem reticular formation

脑干网状结构激活系统中的神经元群

• 发表时间: 2007
• 期刊: Clinical Neuroscience 25
• 作者: Yoshimasa;Koyama;Kazumi;Takahashi
• 通讯作者: Takahashi

Acupuncture stimulation to the sacral segment affects the state of vigilance in rats

针刺骶段对大鼠警觉状态的影响

• 发表时间: 2007
• 期刊: Neurosci Res57
• 作者: Hui Wang;Yoshiyuki Tanaka;Eiich Jodo;Yukihiko Kayama;Akihiro Kawauchi;Tsuneharu Miki;Manabu Otsuki;Yoshimasa Koyama
• 通讯作者: Yoshimasa Koyama

Requirement of tryptophan hydroxylase during development for maturation of sensorimotor gating

• DOI: 10.1016/j.jmb.2006.08.051
• 发表时间: 2006-10-20
• 期刊: JOURNAL OF MOLECULAR BIOLOGY
• 影响因子: 5.6
• 作者: Nakamura, Kazuhiro;Koyama, Yoshimasa;Hirose, Sachiko
• 通讯作者: Hirose, Sachiko

Nitric oxide from the laterodorsal tegmental neurons: Its possible retrograde modulation on norepinephrine release from the axon terminal of the locus coeruleus neurons

• DOI: 10.1016/j.neuroscience.2005.10.063
• 发表时间: 2006-01-01
• 期刊: NEUROSCIENCE
• 影响因子: 3.3
• 作者: Kodama, T;Koyama, Y
• 通讯作者: Koyama, Y

Penile erection and micturition events triggered by electrical stimulation of the mesopontine tegmental area

• DOI: 10.1152/ajpregu.00226.2007
• 发表时间: 2008-01-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
• 影响因子: 2.8
• 作者: Salas, Juan Carlos Toledo;Iwasaki, Hiroshi;Koyama, Yoshimasa
• 通讯作者: Koyama, Yoshimasa