Visualization of oscillation for stress signal and molecular genetic study of establishment of cell community

在动物发育过程中，分化细胞面临着试错过程，并受到内外应激的双重作用。半胱天冬酶作为应激反应之一被激活。在本研究中，我们建立了体内成像系统来监测caspase的激活。细胞死亡和半胱天冬酶激活的实时成像使我们能够记录细胞凋亡信号在发育过程中建立细胞群落的作用。

During animal development, differentiating cells face to trial and error process and acquire both intrinsic and extrinsic stress. Caspases are activated as one of stress responses. In this study, we established in vivo imaging system to monitor caspase activation. Live imaging of cell death and caspase activation allowed us to document the role of apoptosis signaling to establish the cellular communities during development.