DEVELOPMENT OF A VASCULAR REHABILITATION METHOD BASED ON REAL-TIME MEASUREMENT OF PLASMA NITRIC OXIDE CONCENTRATION

基于实时测量血浆一氧化氮浓度的血管康复方法的开发

• 批准号: 19300197
• 负责人: MOCHIZUKI Seiichi
• 金额: $ 11.4万
• 依托单位: Kawasaki University of Medical Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19300197/
• 关键词: 循環器・高血圧; 血管生理学; 血管リハビリテーション; メタボリック症候群; 一酸化窒素(NO); 血管機能; 酸化ストレス; 抗酸化力; 腹膜透析(CAPD); 生理学; リハビリテーション

The patients with ischemic heart diseases and cerebrovascular dysfunctions (major causes of death of the Japanese) suffer from vascular dysfunctions due to atherosclerotic development, and thus it is important to develop vascular rehabilitation methods as well as preventative methods for such vascular diseases. Nitric oxide (NO) is synthesized from endothelial cells in response to changes in blood flow and exerts various physiological functions such as vascular dilatation (controlling blood pressure and blood flow) and anti-atherosclerosis. In this study, we aimed at i) elaborating simultaneous measurement of in vivo NO concentration in the blood stream together with blood pressure and blood flow velocity on a real-time basis and ii) developing a quantitative analytical method for vascular rehabilitation. We were successful not only in developing a measurement technique but also in confirming the applicability of this technique to a quantitative analysis of i) vascular functions of the subjects with metabolic syndrome and ii) other biological functions.

缺血性心脏病和脑血管功能障碍患者（日本人死亡的主要原因）由于动脉粥样硬化的发展而出现血管功能障碍，因此研究血管康复方法和预防方法非常重要。一氧化氮（NO）是由内皮细胞根据血流变化合成的，具有血管扩张（控制血压和血流）、抗动脉粥样硬化等多种生理功能。在本研究中，我们的目标是i)建立同时实时测量体内血流中NO浓度、血压和血流速度的方法；ii)建立血管康复的定量分析方法。我们不仅成功地开发了一种测量技术，而且还确认了该技术对代谢综合征受试者血管功能和其他生物功能的定量分析的适用性。

项目成果

Clear correlation of tetrahydrobiopterin with nitric oxide bioavailability in CAPD

CAPD 中四氢生物蝶呤与一氧化氮生物利用度的明确相关性

• 发表时间: 2010
• 期刊: Blood Purif (印刷中)
• 作者: Mochizuki S;Takayama A;Sasaki T;Yada T;Endo K;Horike H;Kashihara N;Ogasawara Y;Kajiya F
• 通讯作者: Kajiya F

Plasma detection of NO by a catheter

• DOI: 10.1007/s11517-008-0333-z
• 发表时间: 2008-05-01
• 期刊: MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
• 影响因子: 3.2
• 作者: Goto, Masami;Mochizuki, Seiichi
• 通讯作者: Mochizuki, Seiichi