Evaluation of generation process and physiological functional mechanism of nitrate-derived nitric oxide in the vascular system

我们关注的是由亚硝酸盐衍生的一氧化氮（NO），而不是由NO合酶衍生的一氧化氮。首先，我们证实了唾液中含有的亚硝酸盐和饮料中含有的抗氧化剂的混合物会产生NO。接下来，我们发现含抗氧化剂饮料的亚硝酸盐衍生NO的生成取决于这些饮料的抗氧化能力。最后，亚硝酸盐衍生NO的生成与抗氧化能力指标（如BAP和OXY值）呈线性正相关。从而阐明了抗氧化剂在酸性条件下亚硝酸盐衍生NO生成过程中的重要作用。

We have focused on nitric oxide (NO) derived from nitrite, not from NO synthase. First, we confirmed NO generation from a mixture of nitrite contained in saliva and anti-oxidant contained in drinks. Next, it was found that nitrite-derived NO generation with antioxidant-containing drinks depended on the anti-oxidative capacity of these drinks. Finally, positive linear correlations were observed between nitrite-derived NO generation and anti-oxidant capacity indexes such as BAP and OXY values. Thus, we clarified the important roles of anti-oxidants in the process of nitrite-derived NO generation under acidic conditions.