CONFORMATIONAL CHANGE OF NUCLEAR ARCHITECTURE IN RESPONSE TO IONIZING IRRADIATION
CONFORMATIONAL CHANGE OF NUCLEAR ARCHITECTURE IN RESPONSE TO IONIZING IRRADIATION
批准号:
19310037
负责人:
TASHIRO Satoshi
金额:
$12.4万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
We examined the mechanism of human cellular response against ionizing irradiation. For this purpose, we analyzed the structure and dynamics of the radiation-induced nuclear foci and reorganization of damaged chromatin. We found that DNA damage-induced release of histone H2AX, a variant of histone H2A, from damaged chromatin is required for the DNA damage-induced focus formation of RAD51. The release of H2AX from damaged chromatin is regulated by acetylation and ubiquitination of H2AX by TIP60 and UBC13, respectively, We also found that histone H2AZ, another H2A variant, is released from chromatin after induction of DNA damage.
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放射線応答RAD51フォーカスの多様性
辐射响应 RAD51 焦点的多样性
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Jiying SUN, Satoshi Tashiro, 孫 継英, 井倉 毅, 河野 一輝, 島 弘季, 鈴木 秀和, 鈴木 秀和]
通讯作者:
鈴木 秀和
ユビキチン化によって制御されるヒストンH2AXのダイナミクス
泛素化调节组蛋白 H2AX 动力学
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Jiying Sun, Yukako Oma, Masahiko Harata, Kazuteru Kono, Hiroki Shima, Aiko Kinomura, Tsuyoshi Ikura, Shuki Mizutani, 田代聡, 田代聡, Jiying Sun, 島弘季, 井倉毅, 河野一輝, 田代聡, Satoshi Tashiro, Satoshi Tashiro, 田代聡, Satoshi Tashiro, 田代 聡, 井倉 毅]
通讯作者:
井倉 毅
Regulation of heme oxygenase-1 by transcription factor Bachl in the mouse brain
转录因子 Bachl 对小鼠脑中血红素加氧酶 1 的调节
DOI:
--
发表时间:
2008
期刊:
Neuroscience Lett 440
影响因子:
--
作者:
[Sakoda, E, et.al.]
通讯作者:
et.al.
染色体転座形成の分子機構
染色体易位形成的分子机制
DOI:
--
发表时间:
2009
期刊:
放射線生物研究 44
影响因子:
--
作者:
[Ueda C, Tateda K, et al., 舘田一博(分担執筆), Niida H, Kobayashi J, Ishida T, 田代聡, 孫継英]
通讯作者:
孫継英
DOI:
10.1038/nsmb.1504
发表时间:
2008-11
期刊:
Nature structural & molecular biology
影响因子:
16.8
作者:
[]
通讯作者:
共 43 条
Study of the movement of damaged DNA
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批准号:25640066
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2013
-
负责人:TASHIRO Satoshi
-
依托单位:
Study of the memory of genome stress
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批准号:23650588
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:TASHIRO Satoshi
-
依托单位:
Molecular mechanism to construct the DNA repair related higher order nuclear structures
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批准号:22310036
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.56万
-
财政年份:2010
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负责人:TASHIRO Satoshi
-
依托单位:
Dynamics of higher order nuclear architecture upon DNA damage
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批准号:17510045
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2005
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负责人:TASHIRO Satoshi
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依托单位:
Regulation of nuclear domain localization and dynamics
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批准号:16084205
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$39.94万
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财政年份:2004
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负责人:TASHIRO Satoshi
-
依托单位:
Study of the mechanism of apoptosis and drug resistance in leukemic cells
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批准号:15591112
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2003
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负责人:TASHIRO Satoshi
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依托单位:
Cytogenetically analysis of congenital abnormality and childhood malignancy using multicolor FISH methods
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批准号:13670808
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2001
-
负责人:TASHIRO Satoshi
-
依托单位:
海外基金