Molecular mechanism to construct the DNA repair related higher order nuclear structures

高阶核结构的重组被认为在电离辐射后DNA修复中起着重要作用。然而，辐射诱导的核结构重组的确切机制仍不清楚。在这项研究中，我们研究了辐射诱导高阶核结构形成的分子机制。我们发现，Matrin3(MATR3)是一种核结构相关蛋白，参与了DNA修复蛋白RAD51的核内动力学调节。我们还发现MATR3在重组修复活性的调节中发挥作用。这些发现表明，核结构参与了电离辐射后DNA修复的调节。

Reorganization of higher order nuclear structures has been thought to play an important role in DNA repair after ionizing radiation. However, the precise mechanism of radiation-induced reorganization of nuclear architecture is still unclear. In this study, we studied the molecular mechanisms involved in the formation of radiation induced higher order nuclear structures. We found that Matrin3 (MATR3), a nuclear structure-related protein, is involved in the regulation of the intra-nuclear dynamics of DNA repair protein RAD51. We also found that MATR3 plays a role in the regulation of the recombinational repair activity. These findings suggest the involvement of nuclear architecture in the regulation of DNA repair after ionizing radiation.