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Studies on iterative type I polyketide synthases

Studies on iterative type I polyketide synthases
迭代I型聚酮合酶的研究
批准号:
19310139
负责人:
FUJII Isao
金额:
$10.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

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中文摘要
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英文摘要
Polyketide synthases (PKSs) are important enzymes involved in the construction of basic carbon skeletons of polyketides. In this study, structure and reaction control mechanisms by iterative type I PKSs were investigated. On the 6-methylsalicylic acid synthase, a new catalytic domain named "Thioester Hydrolase" domain was identified which is involved in the product release. In addition, new aspects on the reaction control mechanisms of non-reducing type I PKSs, reducing type I PKSs, and PKS-NRPS (non-ribosomal peptide synthase) were identified.
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会议论文
Expression and Functional Analysis of Fungal Polyketide Biosynthesis Genes
真菌聚酮化合物生物合成基因的表达及功能分析
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Nakamura, S. Narumi, T. Yoshiz ato, S-I. Tsutsui, K-I. Iijima, T, Ken Harada, 松田侑大, Masakazu Kobayashi, 徳永欽也, Akiko Noda, 伊藤崇敬, 横里充弘, 徳永欽也, 小林正和, 松田侑大, Hisashi Umeda, Isao Fujii]
通讯作者: Isao Fujii
DOI: --
发表时间: 2007
期刊:
影响因子: --
作者: [Shioji, M., Fukuda, H., Kanzaki, T., Wasada, K., Kanagawa, T., Shimoya, K., Mu, J., Sugimoto, Y., Murata.Y., 杉本幸彦, Y-H. Chooi, Ken Kasahara, Tomomi Moriguchi, 藤井 勲, Tomomi Moriguchi, 藤井 勲, 勢 康代, 森口 智美, 守屋 智博, 南部 夏希, Isao Fujii, Yutaka Ebizuka, Tomomi Moriguchi]
通讯作者: Tomomi Moriguchi
Functional Analysis of Fungal Iterative Type I Polyketide Synthases ATX from Aspergillus terreus
土曲霉真菌迭代 I 型聚酮化合物合成酶 ATX 的功能分析
DOI: --
发表时间: 2007
期刊:
影响因子: --
作者: [Tomomi Moriguchi, Isao Fujii, Yutaka Ebizuka]
通讯作者: Yutaka Ebizuka
DOI: 10.1002/cbic.201000173
发表时间: 2010-06-14
期刊: CHEMBIOCHEM
影响因子: 3.2
作者: [Kasahara, Ken, Miyamoto, Takanori, Fujii, Isao]
通讯作者: Fujii, Isao
20
    Construction of high efficient bio-production systems using filamentous fungi as host organism
    • 批准号:
      13836002
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.3万
    • 财政年份:
      2001
    • 负责人:
      FUJII Isao
    • 依托单位:
    Molecular genetic analysis of enediyne antibiotic biosynthesis genes
    • 批准号:
      06807163
    • 项目类别:
      Grant-in-Aid for General Scientific Research (C)
    • 资助金额:
      $0.38万
    • 财政年份:
      1994
    • 负责人:
      FUJII Isao
    • 依托单位:
    海外基金