Active dynamic manipulation and regenerative technique for damaged cells by using 3-D micro dynamic stimulation

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A new micro actuator-sensor device was developed to induce mechanical local stimulation and to detect local mechanical cellular response. Then, an experimental system was established for cultured adhesive cells. The developed micro device has potentials as notonly a sensor to evaluate local mechanical property but also as an actuator to enforce mechanical local stimulation onto cultured living adhesive cells. The method has shown that the importance and effectiveness of the mechanical stimulations upon cellular activity particularly in the aspect of regenerative technique.