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Dynamic Properties of Biological Soft Tissues and Its Clinical Applications to Internal Organs

生物软组织的动态特性及其在内脏器官中的临床应用

基本信息

批准号：
08680922
负责人：
KOSAWADA Tadashi
金额：
$ 1.54万
依托单位：
Yamagata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08680922/
关键词：
Soft Tissue Dynamic Property Rat Aorta Free Damped Vibration Viscoelasticity Clinical Application Biological Property Human Prostate Tissue ヒト前立腺ヒト前立腺組織バイオプシー

项目摘要

It is commonly pointed out that dynamic properties soft tissues can provede us additional mechanical informations. Therefore, they can be quite significant as one criteria for the method of diagnosis in normal and pathological mammalian internal organs. A new approach is presented here to establish identification for dynamic properties of mammalian biological soft tissues. Its theoreticla principles are developed and possible applications are also investigated. A linear biological soft tissue strip is attached at the tip of small uniform cantilever beam and is modeled by the combination of spring and dashpot. Dynamic properties of this biological soft tissue, which are viscoelastic and have strong dependence upon frequency, are measured as capabilities of vilbration absorber against free damped vibrations of the small cantilever beam. Natural frequency and logarithmic decrement of the vibrations of the whole system are experimentally measured. Then, by enforcing theoretical analysis, e … More lasticity constant and viscous damping coefficient of the tissue are computed to characterize viscoelastic properties of the soft tissues.The normal, hypertrophic and cancerous biopsy specimen, which are picked out from prostate tissue of human, have been used to demonstrate the feasibility of this method. There was a significant correlation between the viscous damping coefficient and elasticity constant in the case of normal and cancer, while in hypertrophic, there was negative correlation. In cancer tissues, though they have a good correlation coefficient, the range is quite narrow, which means that they lost the ability to coordinate structure and function because of the cancer cell. On the other hand, there exists distinctive differences in the gradient of regression line among normal, cancer and hypertrophic. These suggest that the relationships between viscous damping coefficient and elasticity constant provides useful information in diagnosis for the human prostate tissue.Also, aorta wall tissue of normal and the spontaneously hypertensive rat have examined to investigate influences of hypertension and aging upon mechanical properties of the aorta wall tissue. The results suggest that characteristics of dynamic elasticity constant and viscous damping coefficient of the aorta wall tissue can reflect effects of hypertension and aging. The presence or the lack of material adaptation and remodeling of arterial wall may play the main roll for the results obtained. Less

人们普遍认为，软组织的动态特性可以为我们提供更多的力学信息。因此，它们可以作为正常和病理哺乳动物内脏的诊断方法的一个标准是相当重要的。本文提出了一种新的方法来建立哺乳动物生物软组织动力学特性的识别。阐述了其理论原理，并探讨了其可能的应用。在均匀小悬臂梁的顶端附加一个线性生物软组织条，用弹簧和阻尼器组合来模拟。这种生物软组织的动态特性，这是粘弹性的，并具有很强的依赖于频率，作为对小悬臂梁的自由阻尼振动的振动吸收器的能力进行测量。实验测量了整个系统的固有频率和振动的对数衰减率。然后，通过理论分析， ...更多信息通过计算软组织的弹性常数和粘滞阻尼系数来表征软组织的粘弹特性，并以人体前列腺正常组织、增生组织和癌变组织为例，验证了该方法的可行性。正常和癌组织的粘滞阻尼系数与弹性常数呈显著相关，而肥厚组织的粘滞阻尼系数与弹性常数呈负相关。在癌组织中，虽然它们具有良好的相关系数，但范围相当窄，这意味着它们由于癌细胞而失去了协调结构和功能的能力。另一方面，正常人、癌和肥厚型之间的回归线梯度存在显著差异。本文还以正常和自发性高血压大鼠主动脉壁组织为研究对象，探讨了高血压和衰老对主动脉壁组织力学特性的影响。结果表明，主动脉壁组织的动态弹性常数和粘滞阻尼系数的特征可以反映高血压和衰老的影响。动脉壁的材料适应和重塑的存在或缺乏可能对所获得的结果起主要作用。少