The experimental production of the drug delivery system using a bacterial-toxin infection mechanism.

肉毒杆菌毒素复合物具有利用凝集素成分使神经毒素穿越肠上皮屏障的巧妙机制。因此，这一机制的阐明可以应用于新的给药系统和疫苗的开发。在本研究中，我们证明了C型HA3可以与胶原蛋白结合。我们还展示了每个HA1突变体的结构和糖结合位点的特性。这些结果为创建新综合体的实验性规划提供了新的见解。

The botulinum toxin complex has the clever mechanism of the neurotoxin transit across the intestinal epithelial barrier using the lectin components. So it seems that the elucidation of this mechanism can be applied to the new drug delivery system and the vaccine development. In this study, we demonstrate that the type C HA3 can bind to the collagen. We also show the architecture and the properties of sugar-binding site of each HA1 mutants. These results yield new insights into the experimental planning of the creation of new complexes.