Molecular Genetic Analysis of the MAPK Signaling Pathway
Molecular Genetic Analysis of the MAPK Signaling Pathway
批准号:
19390024
负责人:
SUGIURA Reiko
金额:
$11.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2010
中文摘要
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英文摘要
This project aims to identify regulators of MAPK signaling using fission yeast S. pombe as a model organism. We identified negative regulators of Pmk1 MAPK, such as ptc1+, ptc3+, encoding PP2Cs, and ecm33+, encoding a cell surface protein. We also identified targets of Pmk1 including the Atf1 transcription factor and the Nrd1 RNA-binding protein. We also demonstrated feedback mechanisms involving these regulators of Pmk1 MAPK and identified several compounds with potent MAPK inhibitory action.
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Wobble inosine tRNA modiification is essential to cell cycle progression in Gl/S and G2/Mtransitions in fission yeast
摆动肌苷 tRNA 修饰对于裂殖酵母中 G1/S 和 G2/M 转变的细胞周期进程至关重要
DOI:
--
发表时间:
2007
期刊:
J.Biol.Chem 282(46)
影响因子:
--
作者:
[Satoshi Tsutsumi, et. al.]
通讯作者:
et. al.
The Actin Binding Protein Cis3/PSTPIP Is Involved in the Regulation of the Pmkl MAPK Signaling Pathway and Cytokinesis
肌动蛋白结合蛋白 Cis3/PSTPIP 参与 Pmkl MAPK 信号通路和细胞分裂的调节
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[長野 正展, Akihiro Takeda]
通讯作者:
Akihiro Takeda
Stress-Activated Protein Kinase Signaling Regulates Ca2+-Calcineurin Signaling
应激激活蛋白激酶信号调节 Ca2-钙调磷酸酶信号
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Kashiwagi, K., Terui, Y., Higashi, K., Okudaira, H., Ochiai, E., Tomitori, H., Nishimura, K., Yamamoto, K., Ishihama, A., Igarashi, K., 栗原正明, 橋本祐一, Daiki Kanbayashi]
通讯作者:
Daiki Kanbayashi
ダウン症候群原因遺伝子の新たな役割の発見-がん化とストレスとの関係性-
唐氏综合症致病基因的新作用的发现 - 癌症与压力的关系 -
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[大金賢司, どど孝介, 橋本祐一, Reiko Sugiura, 上林大起]
通讯作者:
上林大起
抗がん剤汚染防止バイアル用ゴム栓「もれま栓」プロトタイプの開発
开发用于防止抗癌药物污染的小瓶用橡胶塞原型“Leema Stopper”
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[三田裕介, 他5名, 石渡俊二]
通讯作者:
石渡俊二
共 220 条
Regulatory mechanisms of MAPK signaling and its application to chemicalgenomics
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批准号:23390021
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.73万
-
财政年份:2011
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负责人:SUGIURA Reiko
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依托单位:
Molecular genetic analysis of the RNA-mediated signaling pathways
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批准号:17026034
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$9.09万
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财政年份:2005
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负责人:SUGIURA Reiko
-
依托单位:
Functional analysis of calcineurin-mediated signalling pathways using fission yeast as a model organism
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批准号:14580698
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.86万
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财政年份:2002
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负责人:SUGIURA Reiko
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依托单位:
海外基金