Genesis and physiologic significance of secretory RAGE-a new vasoprotective factor
Genesis and physiologic significance of secretory RAGE-a new vasoprotective factor
批准号:
19390085
负责人:
YAMAMOTO Hiroshi
金额:
$11.48万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2010
中文摘要
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英文摘要
First, we identified cis-acting regulatory elements and a putative trans-acting factor that may participate in the production of secretory RAGE. Second, we created a secretory RAGE-overexpressing transgenic mouse model, and demonstrated with it that RAGE accounts for the transition of amyloid・into the brain. Further, we also found that RAGE is involved in lipopolysaccharide-induced inflammation and in phosphatidyl serine-mediated apoptosis.
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EphA2 is an essential mediator of ultraviolet radiation-induced apoptosis.
EphA2 是紫外线辐射诱导细胞凋亡的重要介质。
DOI:
--
发表时间:
2008
期刊:
Cancer Research 68
影响因子:
--
作者:
[Zhang, G., et. al.]
通讯作者:
et. al.
DOI:
10.1167/iovs.06-0495
发表时间:
2007-02-01
期刊:
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
影响因子:
4.4
作者:
[Kaji, Yuichi, Usui, Tomohiko, Adamis, Anthony P.]
通讯作者:
Adamis, Anthony P.
DOI:
10.1016/j.molcel.2008.02.017
发表时间:
2008-03-28
期刊:
MOLECULAR CELL
影响因子:
16
作者:
[Liu, Zhixue, Jang, Sung-Wuk, Ye, Keqiang]
通讯作者:
Ye, Keqiang
Legumain/asparaginyl endopetidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells.
Legumain/天冬酰胺内肽酶通过降解小鼠肾近端小管细胞中的纤连蛋白来控制细胞外基质重塑。
DOI:
--
发表时间:
2007
期刊:
FEBS. Lett. 581
影响因子:
--
作者:
[Morita, Y., et. al.]
通讯作者:
et. al.
血管内皮細胞における細胞保護性RAGEスプラスバリアント (esRAGE) の産生調節機構
血管内皮细胞中细胞保护性 RAGE 超变体 (esRAGE) 产生的调节机制
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[大江和代]
通讯作者:
大江和代
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