A Role of Adrenomedullin on the development and progression of pulmonary fibrosis and pulmonary emphysema
A Role of Adrenomedullin on the development and progression of pulmonary fibrosis and pulmonary emphysema
批准号:
19790556
负责人:
YAMAMOTO Hiroshi
金额:
$2.42万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
高齢マウスとして22ヶ月齢のAM遺伝子改変マウス(Old AM-KO)およびその同腹子、コントロールとして12週齢のAM遺伝子改変マウス(Young AM-KO)およびその同腹子を準備し、それぞれにおける肺機能、組織学的変化を検討した。まず肺機能については、Old miceにおける残気量(RV),残気率(RV/TLC)の有意な増加が認められた。一方、組織学的な検討の結果、平均肺胞間距離(Lm)がOld miceにおいて有意に長く、肺胞面積や破壊指数(DI)については有意な差を認めなかった。いずれもAM遺伝子改変の有無とは関連を見出せなかった。この高齢マウスに対する慢性喫煙負荷を行うことで老人肺ではなく肺気腫が形成されること、さらにその肺気腫形成にadrenomedullinが抑制的に働くとすればきわめて画期的であり、「老いても肺気腫にはなりにくい」治療法の開発につながる独創的、萌芽的な研究結果を提示しうるものと考えられた。
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