Application of RAGE inhibitor inhalation for COPD

RAGE抑制剂吸入治疗COPD的应用

• 批准号: 23659430
• 负责人: YAMAMOTO Hiroshi
• 金额: $ 2.25万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659430/
• 关键词: 閉塞性肺疾患; RAGE; cAMP; MMP9; MMP; シェディング; A594; BEAS-2B; 定量的RT-PCR

(1) We found that ligand-dependent RAGE signal was suppressed by cAMP-dependent signaling pathway, using mouse macrophage culture system.(2) We showed that cAMP-dependent signal caused activation of MMP9 that accelerated shedding of membrane-bound form RAGE, which resulted in decrease of membrane-bound form RAGE and increase of soluble form RAGE.(3) The mechanism of the suppression of ligand-dependent RAGE signal by cAMP-dependent signal was supposed that the acceleration of shedding of membrane-bound form RAGE via cAMP-dependent signal resulted in decrease of membrane-bound form RAGE functioning signal transducer and increase of soluble form RAGE functioning decoy receptor.

(1)利用小鼠巨噬细胞培养系统，我们发现cAMP依赖性信号通路抑制配体依赖性的cAMP信号。(2)我们发现cAMP依赖性信号引起MMP 9的活化，从而加速膜结合型β-淀粉样蛋白的脱落，这导致膜结合型β-淀粉样蛋白的减少和可溶性β-淀粉样蛋白的增加。(3)cAMP依赖性信号抑制配体依赖性信号的机制可能是cAMP依赖性信号加速膜结合型受体的脱落，导致膜结合型受体功能信号转导子减少，可溶性受体功能诱饵受体增加。

项目成果

RAGE provides a link between genetic susceptibility and environmental factors in type 1 diabetes

RAGE 揭示了 1 型糖尿病的遗传易感性和环境因素之间的联系

• 发表时间: 2011
• 期刊: Diabetologia
• 影响因子: 8.2
• 作者: Soeki;T;et al;Forbes JM et al.
• 通讯作者: Forbes JM et al.

Glucoliptoxicity and inappropriate leptin action induce pancreatic cell apoptosis and impair insulin secretion via RAGE induction

糖脂毒性和不适当的瘦素作用可诱导胰腺细胞凋亡并通过 RAGE 诱导损害胰岛素分泌

• 发表时间: 2012
• 作者: Kusunose;K;et al;Yamamoto Y and Yamamoto H;Dong Han
• 通讯作者: Dong Han

糖尿病合併症の成因についてMSD学術講演会

默沙东关于糖尿病并发症成因的学术讲座

• 发表时间: 2011
• 作者: Ogawa H、Azuma M、Muto S、Nishioka Y;Honjo A、Tezuka T、Uehara H、Izumi K、Itai A、Sone S;山本博
• 通讯作者: 山本博

patial Population Dynamics of mouse Endothelial Progenitor Cells in Diabetes.

糖尿病小鼠内皮祖细胞的空间群体动态。

• 发表时间: 2011
• 作者: Ogawa H;et al.;H Saito
• 通讯作者: H Saito

Anti-HMGB1 monoclonal antibody ameliorates fluid percussion-induced brain injury in rats through protection of BBB and inhibition of inflammatory responses

抗 HMGB1 单克隆抗体通过保护 BBB 和抑制炎症反应改善液体冲击引起的大鼠脑损伤

• 发表时间: 2012
• 期刊: Ann Neurol
• 影响因子: 11.2
• 作者: Ishimura A;Terashima M;Suzuki T;Okuma Y.
• 通讯作者: Okuma Y.